Evidence map›Paper›PMID 33785646›Full record

ArticleMolecular cancer therapeutics2021

Sani H Kizilbash, Shiv K Gupta, Karen E Parrish, Janice K Laramy, Minjee Kim, Gautham Gampa, Brett L Carlson, Katrina K Bakken, Ann C Mladek, Mark A Schroeder and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Small Molecule Tyrosine Kinase Inhibitors (TKIs) for Glioblastoma Treatment.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sani H KizilbashDepartment of Oncology, Mayo Clinic, Rochester, Minnesota. kizilbash.sani@mayo.edu.
Shiv K GuptaDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9107-9935
Karen E ParrishDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Janice K LaramyDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Minjee KimDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Gautham GampaDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Brett L CarlsonDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Katrina K BakkenDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Ann C MladekDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Mark A SchroederDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Paul A DeckerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
William F Elmquist *Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota.
Jann N Sarkaria *Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USUniversity of Minnesota · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Paul Calabresi Program in Clinical/Translational Research at Mayo ClinicK12CA090628 · NCI · MAYO CLINIC ROCHESTER · PI WEROHA, SARAVUT · 2001 to 2025
$19.7M
Trans Network ProjectU54CA210180 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LAUFFENBURGER, DOUGLAS A · 2016 to 2020
$10.2M
Improving Delivery of Molecularly-Targeted Therapy to Invasive Glioma CellsR01CA138437 · NCI · UNIVERSITY OF MINNESOTA · PI ELMQUIST, WILLIAM, OHLFEST, JOHN R · 2010 to 2014
$1.5M
NCI NIH HHS K12 CA090628NCI NIH HHS P30 CA015083NCI NIH HHS R01 CA138437NCI NIH HHS U54 CA210180
6 · The paper itself

Abstract

Tesevatinib is a potent oral brain penetrant EGFR inhibitor currently being evaluated for glioblastoma therapy. Tesevatinib distribution was assessed in wild-type (WT) and

Indexed as

AnimalsAzabicyclo CompoundsBrain NeoplasmsDisease Models, AnimalFemaleGlioblastomaHumansMiceMice, NudeProtein Kinase InhibitorsQuinazolinesSignal TransductionAzabicyclo CompoundsProtein Kinase InhibitorsQuinazolinesXL647

Identifiers

PMID33785646
PMCPMC8172524
OpenAlexW3148102874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.