Evidence map›Paper›PMID 33785633›Full record

ArticlemBio2021

Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium.

Xuan Wang-Kan, Giovanny Rodríguez-Blanco, Andrew D Southam, Catherine L Winder, Warwick B Dunn, Alasdair Ivens, Laura J V Piddock

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 34 citations in OpenAlex.

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  12. Disruption of the EmrAB-TolC efflux pump ofmicroPublication biology · 2025
    Article
  13. Review
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  15. Article
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  17. Multidrug efflux pumps ofFrontiers in microbiology · 2024
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xuan Wang-KanAntimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom xuan.wangkan@ludwig.ox.ac.uk L.J.V.PIDDOCK@bham.ac.uk.
Giovanny Rodríguez-BlancoSchool of Biosciences, The University of Birmingham, Birmingham, United Kingdom.
Andrew D SouthamSchool of Biosciences, The University of Birmingham, Birmingham, United Kingdom.
Catherine L WinderSchool of Biosciences, The University of Birmingham, Birmingham, United Kingdom.
Warwick B DunnSchool of Biosciences, The University of Birmingham, Birmingham, United Kingdom.
Alasdair IvensCentre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom.
Laura J V PiddockAntimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom xuan.wangkan@ludwig.ox.ac.uk L.J.V.PIDDOCK@bham.ac.uk.ORCID 0000-0003-1460-473X
University of Birmingham · GBCentre for Immunity, Infection and Evolution · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L024209/1Medical Research Council MR/M009157/1Medical Research Council MR/P022596/1
6 · The paper itself

Abstract

In the fight against antibiotic resistance, drugs that target resistance mechanisms in bacteria can be used to restore the therapeutic effectiveness of antibiotics. The multidrug resistance efflux complex AcrAB-TolC is the most clinically relevant efflux pump in

Indexed as

Anti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialMembrane Transport ProteinsMetabolomicsSalmonella typhimuriumAcrB protein, E coliAcrB protein, Salmonella entericaAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsEscherichia coli ProteinsMembrane Transport ProteinsAcrABAcrAB-TolCdrug effluxeffluxefflux pumpsEnterobacteralesEscherichia coliphysiological substratesSalmonella

Identifiers

PMID33785633
PMCPMC8092203
OpenAlexW3141126148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.