Evidence map›Paper›PMID 33785629›Full record

ArticlemBio2021

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials.

Kensuke Shima, Inga Kaufhold, Thomas Eder, Nadja Käding, Nis Schmidt, Iretiolu M Ogunsulire, René Deenen, Karl Köhrer, Dirk Friedrich, Sophie E Isay and 7 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Cellular signaling meets bacterial infection: the integrative role of STAT3.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. TheApplied and environmental microbiology · 2024
    Article
  9. Review
  10. Article
  11. Diagnostics (Basel, Switzerland) · 2022
    Review
  12. Insights Into Mitochondrial Dynamics in Chlamydial Infection.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Impact of First-Line Antimicrobials onFrontiers in microbiology · 2021
    Article
  14. Robust Heat Shock Response inFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Kensuke ShimaDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany kensuke.shima@uksh.de.ORCID 0000-0002-5357-4230
Inga KaufholdDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Thomas EderDivision of Computational Systems Biology, University Vienna, Vienna, Austria.
Nadja KädingDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Nis SchmidtDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Iretiolu M OgunsulireDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
René DeenenBiological and Medical Research Center (BMFZ), Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Karl KöhrerBiological and Medical Research Center (BMFZ), Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Dirk FriedrichDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.ORCID 0000-0001-8812-489X
Sophie E IsayDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Florian GrebienInstitute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria.
Matthias KlingerInstitute of Anatomy, University of Lübeck, Lübeck, Germany.
Barbara C RicherInstitute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany.
Ulrich L GüntherInstitute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany.
George S DeepeDivision of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Thomas RatteiDivision of Computational Systems Biology, University Vienna, Vienna, Austria.
Jan RuppDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.ORCID 0000-0001-8722-1233
University of Lübeck · DEHeinrich Heine University Düsseldorf · DEUniversity of Vienna · ATGerman Center for Infection Research · DEUniversity of Cincinnati Medical Center · USUniversity of Veterinary Medicine Vienna · AT

Funding

GM-CSF-Induced Metal Sequestration and HistoplasmaR01AI106269 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2013 to 2022
$5.0M
HIF Regulation of Histoplasma PathogenesisR01AI133797 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI106269NIAID NIH HHS R01 AI133797
6 · The paper itself

Abstract

Infection with the obligate intracellular bacterium

Indexed as

Anti-Bacterial Agentsbeta-LactamsChlamydia InfectionsChlamydia trachomatisFatty AcidsHeLa CellsHumansMitochondriaSTAT3 Transcription FactorAnti-Bacterial Agentsbeta-LactamsFatty AcidsSTAT3 Transcription Factorbeta-lactamsChlamydia trachomatiscitratefatty acidsmetabolismmitochondriapenicillinpersistenceprotein tyrosine phosphataseSTAT3

Identifiers

PMID33785629
PMCPMC8092193
OpenAlexW3145431863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.