Evidence map›Paper›PMID 33785598›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

A unique Malpighian tubule architecture in

Takashi Koyama, Muhammad Tayyib Naseem, Dennis Kolosov, Camilla Trang Vo, Duncan Mahon, Amanda Sofie Seger Jakobsen, Rasmus Lycke Jensen, Barry Denholm, Michael O'Donnell, Kenneth Veland Halberg

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  4. Article
  5. Review
  6. NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Takashi KoyamaDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark.ORCID 0000-0003-4203-114X
Muhammad Tayyib NaseemDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark.ORCID 0000-0002-6225-9777
Dennis KolosovDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-3581-9991
Camilla Trang VoDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Duncan MahonDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Amanda Sofie Seger JakobsenDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark.ORCID 0000-0001-6969-6577
Rasmus Lycke JensenDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Barry DenholmCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.ORCID 0000-0001-5785-2552
Michael O'DonnellDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-3988-6059
Kenneth Veland HalbergDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark; kahalberg@bio.ku.dk.ORCID 0000-0002-5903-7196
University of Copenhagen · DKCalifornia State University, San Marcos · USMcMaster University · CAUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining internal salt and water balance in response to fluctuating external conditions is essential for animal survival. This is particularly true for insects as their high surface-to-volume ratio makes them highly susceptible to osmotic stress. However, the cellular and hormonal mechanisms that mediate the systemic control of osmotic homeostasis in beetles (Coleoptera), the largest group of insects, remain largely unidentified. Here, we demonstrate that eight neurons in the brain of the red flour beetle

Indexed as

Evolution, MolecularWater-Electrolyte BalanceAnimalsBrainInsect HormonesMalpighian TubulesNeuronsTriboliumInsect Hormonesdiuretic hormoneMalpighian tubuleosmoregulationsecondary cellTribolium castaneum

Identifiers

PMID33785598
PMCPMC8040626
OpenAlexW3143290957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.