Evidence map›Paper›PMID 33785594›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in

Surya D Aggarwal, Adrian J Lloyd, Saigopalakrishna S Yerneni, Ana Rita Narciso, Jennifer Shepherd, David I Roper, Christopher G Dowson, Sergio R Filipe, N Luisa Hiller

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Clinical microbiology reviews · 2025
    Review
  6. Article
  7. Colonization dynamics ofInfection and immunity · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Microbiology spectrum · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Surya D AggarwalDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0001-8900-6684
Adrian J LloydSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom; adrian.lloyd@warwick.ac.uk sfilipe@fct.unl.pt lhiller@andrew.cmu.edu.ORCID 0000-0002-4638-4586
Saigopalakrishna S YerneniDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0003-4837-5592
Ana Rita NarcisoLaboratory of Bacterial Cell Surfaces and Pathogenesis, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 1099-085 Oeiras, Portugal.ORCID 0000-0003-1316-3856
Jennifer ShepherdSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.
David I RoperSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0003-0009-621X
Christopher G DowsonSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0002-8294-8836
Sergio R FilipeLaboratory of Bacterial Cell Surfaces and Pathogenesis, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 1099-085 Oeiras, Portugal; adrian.lloyd@warwick.ac.uk sfilipe@fct.unl.pt lhiller@andrew.cmu.edu.ORCID 0000-0002-4485-832X
N Luisa HillerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213; adrian.lloyd@warwick.ac.uk sfilipe@fct.unl.pt lhiller@andrew.cmu.edu.ORCID 0000-0001-6572-1368
University of Warwick · GBCarnegie Mellon University · USUniversidade Nova de Lisboa · PT

Funding

Insights from Comparative Genomics for the Treatment of Pneumococcal InfectionsR00DC011322 · NIDCD · CARNEGIE-MELLON UNIVERSITY · PI HILLER, NATALIA LUISA · 2012 to 2014
$718k
Medical Research Council G0400848Medical Research Council G1100127Medical Research Council MR/N002679/1NIDCD NIH HHS R00 DC011322
6 · The paper itself

Abstract

Survival in the human host requires bacteria to respond to unfavorable conditions. In the important Gram-positive pathogen

Indexed as

Cell DivisionAnimalsBacterial ProteinsCell LineCell WallMacrophagesMiceOperonPeptide SynthasesPhagocytosisRNA, TransferStreptococcus pneumoniaeBacterial ProteinsMurM protein, Streptococcus pneumoniaePeptide SynthasesRNA, Transferautolysiscell wallStreptococcus pneumoniaestringent responsetranslation quality control

Identifiers

PMID33785594
PMCPMC8040666
OpenAlexW3150704740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.