Evidence map›Paper›PMID 33785592›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

CD11c

Navid Manouchehri, Rehana Z Hussain, Petra D Cravens, Ekaterina Esaulova, Maxim N Artyomov, Brian T Edelson, Gregory F Wu, Anne H Cross, Richard Doelger, Nicolas Loof and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Distinctive transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. CD317 puts the brakes on dendritic cell trafficking to the CNS.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Navid ManouchehriDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-5773-2622
Rehana Z HussainDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-7700-913X
Petra D CravensDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ekaterina EsaulovaDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Maxim N ArtyomovDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Brian T EdelsonDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2856-7650
Gregory F WuDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-3588-0637
Anne H CrossDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-0829-7569
Richard DoelgerDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Nicolas LoofThe Moody Foundation Flow Cytometry Facility, Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-3362-5344
Todd N EagarDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030.
Thomas G ForsthuberDepartment of Biology, University of Texas at San Antonio, San Antonio, TX 78249.ORCID 0000-0003-0692-7125
Laurent CalvierDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-6437-2119
Joachim HerzDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Olaf StüveDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390; olaf.stuve@utsouthwestern.edu.ORCID 0000-0002-0469-6872
The University of Texas Southwestern Medical Center · USWashington University in St. Louis · USMethodist Hospital · USMoody Foundation · USThe University of Texas at San Antonio · USUniversity of Freiburg · DEVA North Texas Health Care System · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
The Role of TRPV4 in central nervous system immunity and diseaseR01NS106289 · NINDS · WASHINGTON UNIVERSITY · PI WU, GREGORY · 2018 to 2021
$1.6M
Determining the compartmental role of B cell subsets during CNS autoimmunityI01BX001674 · VA · VA NORTH TEXAS HEALTH CARE SYSTEM · PI STUVE, OLAF · 2013 to 2016
–
BLRD VA I01 BX001674BLRD VA I01 BX005664NCATS NIH HHS UL1 TR002345NINDS NIH HHS R01 NS106289
6 · The paper itself

Abstract

Natalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c

Indexed as

AnimalsAntigen PresentationAntigens, CDCells, CulturedCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansIntegrin alpha4MaleMiceMicrogliaMyeloid CellsAntigens, CDIntegrin alpha4biomarkerCD317EAEmultiple sclerosismyeloid cells

Identifiers

PMID33785592
PMCPMC8040603
OpenAlexW3148634679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.