Evidence map›Paper›PMID 33785522›Full record

ArticleeNeuro

Different Effects of Alcohol Exposure on Action and Outcome-Related Orbitofrontal Cortex Activity.

Christian Cazares, Drew C Schreiner, Christina M Gremel

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christian CazaresThe Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093.
Drew C SchreinerDepartment of Psychology, University of California San Diego, La Jolla, CA 92093.
Christina M GremelThe Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093 cgremel@ucsd.edu.
University of California, San Diego · US

Funding

Dependence induced dysfunction of decision-making circuits.R01AA026077 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christina M. Gremel · 2017 to 2026
$3.8M
Alcohol dependence induced aberrant persistence of reward-seeking and its corticostriatal determinants.F31AA027439 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHREINER, DREW CLINTON · 2019 to 2020
$75k
Investigating the Effects of Alcohol Dependence on the Neural Circuitry Supporting Decision-Making BehaviorF99NS120434 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAZARES, CHRISTIAN · 2021 to 2022
$72k
NIAAA NIH HHS F31 AA027439NIAAA NIH HHS R01 AA026077NINDS NIH HHS F99 NS120434
6 · The paper itself

Abstract

Alcohol dependence can result in long-lasting deficits to decision-making and action control. Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for outcome-related contributions to goal-directed actions during decision-making. Prior work has shown that alcohol dependence induces long-lasting changes to OFC function that persist into protracted withdrawal and disrupts goal-directed control over actions. However, it is unclear whether these changes in function alter representation of action and outcome-related neural activity in OFC. Here, we used the well-validated chronic intermittent ethanol (CIE) exposure and withdrawal procedure to model alcohol dependence in mice and performed

Indexed as

AlcoholismBehavior, AddictiveAnimalsEthanolMiceMice, Inbred C57BLPrefrontal CortexEthanolactionalcoholcompulsivedependencedevaluationorbitofrontal cortex

Identifiers

PMID33785522
PMCPMC8174034
OpenAlexW3143731966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.