ArticleEvidence-based mental health2021
Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study.
Article in Evidence-based mental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 57 citations in OpenAlex.
- Using a Person-Centred Approach to Adapt a Digital Therapy for Inflammatory Bowel Disease (COMPASS-IBD).Health expectations : an international journal of public participation in health care and health policy · 2026Trial
- The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage.BMC gastroenterology · 2025Trial
- Experiences and perceptions of IBD-related psychological distress in persons living with IBD.Journal of the Canadian Association of Gastroenterology · 2026Article
- A Pilot Study of the Real-World Impact of Digital Cognitive Behavioral Therapy for Inflammatory Bowel Disease (COMPASS-IBD) on Inflammation, Disease Activity, and Healthcare Use.Biopsychosocial science and medicine · 2026Article
- Psychological distress predicts disease activity in inflammatory bowel disease: Results from the mind-body IBD longitudinal study.Brain, behavior, & immunity - health · 2026Article
- Depression and Gastrointestinal Health Abnormalities: Treatment Approaches from the Perspective of Traditional Chinese Medicine.Neuropsychiatric disease and treatment · 2026Review
- Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk.Depression and anxiety · 2026Review
- Delivery of evidence-based interventions for psychological distress in persons living with IBD: a roadmap for human-centred design and implementation.Journal of the Canadian Association of Gastroenterology · 2025Article
- Endometriosis, symptoms, and risk for depression and/or anxiety: a population-based retrospective study.BMC women's health · 2025Article
- Glucagon-like peptide-1 (GLP-1) receptor agonists in inflammatory bowel disease: mechanisms, clinical implications, and therapeutic potential.Journal of Crohn's & colitis · 2025Review
- The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.Behavioral and brain functions : BBF · 2025Article
- Consensus Statement on Managing Anxiety and Depression in Individuals with Inflammatory Bowel Disease.Inflammatory bowel diseases · 2025Article
- Impact of Depression on Health-Related Quality of Life in Ulcerative Colitis Patients-Are We Doing Enough? A Single Tertiary Center Experience.Life (Basel, Switzerland) · 2025Article
- Nutritional psychology and inflammatory bowel disease: a narrative review of gut-brain axis interactions.Frontiers in nutrition · 2025Review
- The IBD-disk accurately assesses disability and psychological burden at IBD diagnosis and predicts adverse outcomes in both UC and Crohn's disease during the first year of treatment: a prospective observational cohort study.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Impact of Nursing Interventions via Telephone and Email on the Quality of Life of Patients with Inflammatory Bowel Disease: Preliminary Results of a Comparative Observational Study.Healthcare (Basel, Switzerland) · 2024Article
- Alleviation of Immobilization Stress or Fecal Microbiota-Induced Insomnia and Depression-like Behaviors in Mice byNutrients · 2024Article
- The extracellular vesicle of depressive patient-derived Escherichia fergusonii induces vagus nerve-mediated neuroinflammation in mice.Journal of neuroinflammation · 2024Article
- Prevalence and risk factors of depression among patients with perianal fistulizing Crohn's disease.World journal of psychiatry · 2024Article
- Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study.United European gastroenterology journal · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease (IBD) has a significant impact on quality of life for many people.
objectiveTo assess the prevalence of common mental health conditions in IBD and the combined impact of IBD and mental health conditions on healthcare use and time off work.
methodsA UK population-based primary care database (Royal College of General Practitioners Research and Surveillance Centre) was used to identify adults with IBD (n=19 011) (Crohn's disease (CD) or ulcerative colitis (UC)), and matched controls (n=76 044). Prevalences of anxiety, depressive episodes and depressive disorder recorded in primary care were assessed between 2016 and 2018. Outcomes comprised of rates of primary care visits, emergency secondary care visits, certificates for time off work, antidepressant and anxiolytic prescriptions.
findingsMental health conditions were more common in people with CD than controls: anxiety episodes (3.5% vs 3.0%; p=0.02), depressive episodes (5.7% vs 4.1%; p<0.001) and depressive disorder (17.5% vs 12.9%; p<0.001), and people with UC versus controls: depressive episodes (4.4% vs 3.6%; p<0.001) and depressive disorder (14.2% vs 12.4%; p<0.001). Healthcare utilisation rates were higher in people with IBD than controls (primary care visits incidence rate ratio 1.47 (95% CI 1.43 to 1.51); emergency secondary care visits 1.87 (1.79 to 1.95); fitness for work certificates 1.53 (1.44 to 1.62); antidepressant use 1.22 (1.13 to 1.32); anxiolytic use 1.20 (1.01 to 1.41)). In people with IBD, mental health conditions were associated with additional increases in healthcare use and time off work.
conclusionDepression and anxiety are more common in people with IBD than matched controls. Healthcare utilisation and prescribing of psychotropic medications are also higher in people with IBD. Mental health conditions in people with IBD are associated with additional healthcare use and time off work. CLINICAL IMPLICATIONS: Evidence-based mental health support programmes, including psychological treatments, are needed for people with IBD.
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