Evidence map›Paper›PMID 33785439›Full record

ArticlePhotodiagnosis and photodynamic therapy2021

Macular vessel density in patients recovered from COVID 19.

Leyla Hazar, Mine Karahan, Esra Vural, Sedat Ava, Seyfettin Erdem, Mehmet Emin Dursun, Uğur Keklikçi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  12. The impact of acute COVID-19 on the retinal microvasculature assessed with multimodal imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
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  20. Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leyla HazarDicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey. Electronic address: leyla.hazar@dic.edu.tr.
Mine KarahanDicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey.
Esra VuralKayseri City Hospital, Department of Ophthalmology, Kayseri, Turkey.
Sedat AvaDicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey.
Seyfettin ErdemDicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey.
Mehmet Emin DursunDicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey.
Uğur KeklikçiDicle University, School of Medicine, Department of Ophthalmology, Diyarbakır, Turkey.
Dicle University · TRKayseri Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose is to evaluate macular vascular densities (VDs) using optical coherence tomography angiography (OCTA) in patients effected by coronavirus disease-2019 (COVID-19).

methodsThe superficial (SF) and deep macular VD of 50 patients with SARS CoV2 pneumonia who had positive polymerase chain reaction (PCR) tests and who recovered after receiving treatment and 55 healthy age- and gender-matched controls were compared using OCTA. Blood inflammation parameters were also recorded.

resultsThere was no statistically significant difference between the two groups in terms of age and gender (p = 0.147 and p = 0.504, respectively). Nor was there a difference with respect to smokers between the two groups (p = 0.231). In COVID-19 patients, the VDs in superior hemi quadrant, superior quadrant and inferior quadrant, were significantly lower (p = 0.033, p = 0.029 and p = 0.042, respectively) in superficial plexus. It was also significantly lower in parafovea, superior hemi and superior quadrants (p = 0.026, p < 0.001 and p = 0.004, respectively) in deep plexus. In addition, white blood cell and neutrophil counts were significantly negatively correlated with the VD of the deep parafovea, deep superior quadrant and deep superior hemi quadrant (p < 0.05). There was no difference between the patient and control groups in both superficial and deep foveal avascular zone (FAZ) (p = 0.101 and p = 0.691 respectively).

conclusionIn COVID-19 disease, VD is low in some sectors in both SF and deep layers, but no change in FAZ. The effect of COVID 19 disease on the retina and whether it makes the retina sensitive to damage can only be understood with long-term follow-up.

Indexed as

COVID-19PhotochemotherapyFluorescein AngiographyHumansPhotosensitizing AgentsRetinal VesselsSARS-CoV-2Tomography, Optical CoherencePhotosensitizing AgentsCOVID-19EyeOptical coherence tomography angiographyPandemicRetinal vesselsVascular density

Identifiers

PMID33785439
PMCPMC7999941
OpenAlexW3142022312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.