Evidence map›Paper›PMID 33785155›Full record

ReviewInternational review of neurobiology2021

Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.

Jen-Hau Yang, Alex C Kwan

Abstract readReview
In one paragraph

Review in International review of neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jen-Hau YangDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Alex C KwanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, United States. Electronic address: alex.kwan@yale.edu.

Funding

A Dendritic Substrate for Fast-Acting Antidepressant ActionR01MH121848 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2020 to 2024
$2.6M
Frontal cortical neural dynamics and chronic social stressR01MH112750 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2017 to 2021
$2.1M
Frontal cholinergic signals during value-based decision-makingR21MH118596 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2018 to 2019
$461k
NIMH NIH HHS R01 MH112750NIMH NIH HHS R01 MH121848NIMH NIH HHS R21 MH118596
6 · The paper itself

Abstract

Medial secondary motor cortex (MOs or M2) constitutes the dorsal aspect of the rodent medial frontal cortex. We previously proposed that the function of MOs is to link antecedent conditions, including sensory stimuli and prior choices, to impending actions. In this review, we focus on the long-range pathways between MOs and other cortical and subcortical regions. We highlight three circuits: (1) connections with visual and auditory cortices that are essential for predictive coding of perceptual inputs; (2) connections with motor cortex and brainstem that are responsible for top-down, context-dependent modulation of movements; (3) connections with retrosplenial cortex, orbitofrontal cortex, and basal ganglia that facilitate reward-based learning. Together, these long-range circuits allow MOs to broadcast choice signals for feedback and to bias decision-making processes.

Indexed as

Decision MakingMotor CortexAnimalsBiasCortical circuitDecision-makingFeedbackLong-range projectionMedial agranular cortexMedial frontal cortexMotorPerceptualPremotor

Identifiers

PMID33785155
PMCPMC8190828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.