Evidence map›Paper›PMID 33785117›Full record

SynthesisDeutsches Arzteblatt international2021

Protection From COVID-19–The Efficacy of Face Masks.

Christoph Josef Hemmer, Frank Hufert, Stefan Siewert, Emil Reisinger

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Deutsches Arzteblatt international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Effectiveness of cloth face masks to prevent viral spread: a meta-analysis.Journal of public health (Oxford, England) · 2024
    Pooled it
  2. Pooled it
  3. Review
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  12. Effects of Wearing FFP2 Masks on SARS-CoV-2 Infection Rates in Classrooms.International journal of environmental research and public health · 2022
    Article
  13. Observational
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  15. Review
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  17. Article
  18. [COVID-19 outbreak investigation in a geriatric palliative hospital].Zeitschrift fur Gerontologie und Geriatrie · 2021
    Article
  19. Article
  20. Sensitivity analysis of SARS-CoV-2 aerosol exposure.GMS hygiene and infection control · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Christoph Josef HemmerDepartment of Tropical Medicine and Infectious Diseases, Rostock University Medical CenterDepartment of Microbiology & Virology, Brandenburg Medical School Theodor FontaneInstitute for Implant Technology and Biomaterials (IIB); Rostock University Medical Center.
Frank Hufert
Stefan Siewert
Emil Reisinger
University Medical Center · USUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince the beginning of 2020 the SARS-CoV-2 virus has spread to nearly every country in the world. The mainly airborne pathogen has led to large numbers of deaths, principally in elderly and vulnerable segments of the population. Protective vaccines have recently become available, but it is not yet clear whether and when population-wide immunity will be achieved. The existence of evidence for the protective effect of masks covering the mouth and nose is a topic of public debate.

methodsA selective literature search was carried out in PubMed. Data from the German Robert Koch Institute and the Centers for Disease Control and Prevention were also taken into account.

resultsWhen talking, as many as 20 000 droplets ranging in size from 20 to 500 μM are released every second. According to PCR tests, the amount of virus exhaled is highest immediately before the onset of symptoms. No randomized trials have been conducted on the effect of masks covering the mouth and nose. A metaanalysis of 29 studies on infection with SARS-CoV-2, SARS, or MERS revealed that type N-95 masks (corresponding approximately to FFP-2), surgical masks, or similar multilayer cotton masks can greatly reduce the infection risk for the wearers (RR 0.34 [0.26; 0.45], with moderate heterogeneity [I2 = 48%]). Model experiments and case reports suggest that masks covering the mouth and nose afford considerable protection against transmission of SARS-CoV-2 and other airborne diseases by reducing release of and exposure to potentially infectious droplets; in addition, infections that do occur take a milder course. A limitation of the studies analyzed is that in most cases, this effect cannot be viewed in isolation from the protective impact of other measures (distancing, hygiene precautions).

conclusionIt can plausibly be assumed that consistent use of masks covering the mouth and nose can play an important role in containing the spread of SARSCoV- 2.

Indexed as

COVID-19AgedHumansMasksSARS-CoV-2United States

Identifiers

PMID33785117
PMCPMC8188409
OpenAlexW3121702856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.