Trial reportBMC pregnancy and childbirth2021
Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial.
Trial report in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04500743 (Role of Suppression of Endometriosis With Progestins Before IVF-ET), which is not on this map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Suppression of Endometriosis With Progestins Before IVF-ET: a Non-inferiority Randomized Controlled Trial
Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Efficacy of different pretreatments in IVF outcomes in patients with endometriosis: A systematic review and network meta‑analysis.Scientific reports · 2026Pooled it
- Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Progestagens for pain symptoms associated with endometriosis.The Cochrane database of systematic reviews · 2025Pooled it
- Efficacy of hormone pre-treatment before ART to improve reproductive outcomes in infertile women with endometriosis: Network meta-analysis of randomized controlled trials.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Pooled it
- Impact of dienogest pretreatment on IVF-ET outcomes in patients with endometriosis: a systematic review and meta-analysis.Journal of ovarian research · 2023Pooled it
- A novel approach to treating Endometriosis-Related Repeated IVF failures- insights from single case report.Reproductive biology and endocrinology : RB&E · 2026Article
- Clinical challenges and therapeutic strategies in women with endometriosis, deep infiltrating endometriosis, and/or adenomyosis undergoing assisted reproductive technologies: a narrative review.Frontiers in reproductive health · 2026Review
- Women with endometriosis who undergo IVF: a contemporary review of therapeutic strategies for successful outcomes.Reproductive biology and endocrinology : RB&E · 2025Review
- Progestins - a review of clinical application in gynecology.Annals of medicine · 2025Review
- Review
- An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry.iScience · 2024Article
- A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment.International journal of molecular sciences · 2023Review
- Expectant, Medical, and Surgical Management of Ovarian Endometriomas.Journal of clinical medicine · 2023Review
- Quality of Life During Pregnancy from 2011 to 2021: Systematic Review.International journal of women's health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometriosis affects the responsiveness to ovarian stimulation. This study aimed to assess the role of Dienogest pretreatment for endometriosis suppression as compared to Gonadotropin-releasing hormone agonist (GnRHa) in patients with endometriosis pursuing IVF treatment.
methodsIn this randomized controlled trial, 134 women with endometriosis-related infertility were randomly allocated to group A (n = 67) who had monthly depot GnRHa for 3 months before ovarian stimulation in IVF treatment (Ultra-long protocol), and Group B (n = 67) who had daily oral Dienogest 2 mg/d for 3 months before starting standard long protocol for IVF. The primary outcome measure was the number of oocytes retrieved. The secondary outcome measures included the number of mature oocytes, fertilization rate, quality of life assessed by FertiQoL scores, cost of treatment, and pregnancy outcomes.
resultsAlthough there was no statistically significant difference between both groups regarding ovarian stimulation, response parameters, and pregnancy outcomes, the Dienogest group had a lower cost of treatment (2773 vs. 3664 EGP, P < 0.001), lower side effects (29.9% vs. 59.7%, P < 0.001), higher FertiQoL treatment scores (33.2 vs. 25.1, P < 0.001) and higher tolerability scores (14.1 vs. 9.4, P < 0.001 < 0.001).
conclusionOur study indicates that Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients.
trial registrationNCT04500743 "Retrospectively registered on August 5, 2020".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.