Trial reportStroke2021
Prestroke Physical Activity and Adverse Health Outcomes After Stroke in the Atherosclerosis Risk in Communities Study.
Trial report in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Physical activity prior to transient ischaemic attack and risk of subsequent cerebrovascular events: a Swedish register-based study.BMJ open · 2026Article
- Association of Daily Activity Regularity With Functional Recovery in Patients With Stroke and Spinal Cord Injury: A Prospective Actigraphy Study.Annals of rehabilitation medicine · 2026Article
- Moderate pre-stroke physical activity has a protective effect on symptoms of depression in the post-acute phase after stroke.Scientific reports · 2026Article
- Low physical activity-related disease burden, 1990-2021: assessment of global trends and social determinants based on GBD 2021 data.Journal of global health · 2025Article
- Mid-life physical activity and calcification of coronary arteries, aorta, and cardiac valves in late life: The Atherosclerosis Risk in Communities (ARIC) study.Atherosclerosis · 2025Article
- Premorbid physical activity and prognosis after incident myocardial infarction: The atherosclerosis risk in communities study.American heart journal · 2024Article
- Association between physical activity changes and incident myocardial infarction after ischemic stroke: a nationwide population-based study.BMC public health · 2024Article
- Domain-Specific Physical Activity and Stroke in Sweden.JAMA network open · 2024Article
- Parity and Risk of Dementia in Women: The Atherosclerosis Risk in Communities Study.Journal of women's health (2002) · 2023Article
- Associations of Prestroke Physical Activity With Stroke Severity and Mortality After Intracerebral Hemorrhage Compared With Ischemic Stroke.Neurology · 2022Article
- American Heart Association EPI|Lifestyle Scientific Sessions: 2021 Meeting Highlights.Journal of the American Heart Association · 2022Article
- Pre-stroke physical activity in relation to post-stroke outcomes - linked to the International Classification of Functioning, Disability and Health (ICF): A scoping review.Journal of rehabilitation medicine · 2022Article
- COMIRESTROKE-A clinical study protocol for monitoring clinical effect and molecular biological readouts ofFrontiers in neurology · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
background and purposeThe association of physical activity (PA) before stroke (prestroke PA) with long-term prognosis after stroke is still unclear. We examined the association of prestroke PA with adverse health outcomes in the ARIC study (Atherosclerosis Risk in Communities).
methodsWe included 881 participants with incident stroke occurring between 1993 and 1995 (visit 3) and December 31, 2016. Follow-up continued until December 31, 2017 to allow for at least 1-year after incident stroke. Prestroke PA was assessed using a modified version of the Baecke questionnaire in 1987 to 1989 (visit 1) and 1993 to 1995 (visit 3), evaluating PA domains (work, leisure, and sports) and total PA. We used Cox proportional hazards models to quantify the association between tertiles of accumulated prestroke PA levels over the 6-year period between visits 1 and 3 and mortality, risk of cardiovascular disease, and recurrent stroke after incident stroke.
resultsDuring a median follow-up of 3.1 years after incident stroke, 676 (77%) participants had adverse outcomes. Highest prestroke total PA was associated with decreased risks of all-cause mortality (hazard ratio, 0.78 [95% CI, 0.63-0.97]) compared with lowest tertile. In the analysis by domain-specific PA, highest levels of work PA were associated with lower risk for all-cause (hazard ratio, 0.77 [95% CI, 0.62-0.96]) and cardiovascular mortality (hazard ratio, 0.45 [95% CI, 0.29-0.70]), and highest levels of leisure PA were associated with lower all-cause mortality (hazard ratio, 0.72 [95% CI, 0.58-0.89]) compared with lowest tertile of PA. No significant associations for sports PA were observed.
conclusionsHigher levels of total prestroke PA as well as work and leisure PA were associated with lower risk of mortality after incident stroke. Public health strategies to increase lifetime PA should be encouraged to decrease long-term mortality after stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.