Evidence map›Paper›PMID 33784693›Full record

ReviewGerontology2021

Immunotherapy and Radiotherapy for Older Cancer Patients during the COVID-19 Era: Proposed Paradigm by the International Geriatric Radiotherapy Group.

Nam Phong Nguyen, Brigitta G Baumert, Eromosele Oboite, Micaela Motta, Gokula Kumar Appalanaido, Meritxell Arenas, Pedro Carlos Lara, Marta Bonet, Alice Zamagni, Te Vuong and 6 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 10 countries.

Nam Phong NguyenDepartment of Radiation Oncology, Howard University, Washington, District of Columbia, USA.
Brigitta G BaumertInstitute of Radiation Oncology, Cantonal Hospital Graubünden, Chur, Switzerland.
Eromosele OboiteDepartment of Radiation Oncology, Howard University, Washington, District of Columbia, USA.
Micaela MottaDepartment of Radiation Oncology, Hospital Papa Giovanni XXIII, Bergamo, Italy.
Gokula Kumar AppalanaidoAdvanced Medical & Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.
Meritxell ArenasDepartment of Radiation Oncology, Sant Joan de Reus University, University Rovira I Virgili, Tarragona, Spain.
Pedro Carlos LaraDepartment of Radiation Oncology, Fernando Pessoa Canarias Las Palmas University, Las Palmas, Spain.
Marta BonetDepartment of Radiation Oncology, Arnau de Villanova University Hospital, Lleida, Spain.
Alice ZamagniRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, and Department of Experimental, Diagnostic, and Specialty Medicine, -DIMES, Alma Mater Studiorum Bologna University, Bologna, Italy.
Te VuongDepartment of Radiation Oncology, McGill University, Montreal, Québec, Canada.
Tiberiu PopescuDepartment of Radiation Oncology, Amethyst Radiotherapy Center, Cluj, Romania.
Ulf KarlssonDepartment of Radiation Oncology, International Geriatric Radiotherapy Group, Washington, District of Columbia, USA.
Lurdes TrigoService of Brachytherapy, Instituto Portugues de Oncologia Francisco Martins Porto E.P.E., Porto, Portugal.
Arthur Sun MyintDepartment of Radiation Oncology, Clatterbridge Cancer Center, Liverpool, United Kingdom.
Juliette ThariatDepartment of Radiation Oncology, Baclesse Cancer Center, Caen, France.
Vincent Vinh-HungDepartment of Radiation Oncology, University Hospital of Martinique, Martinique, France.
Howard University · USAzienda USL di Bologna · ITCentre François Baclesse · FRCentre Hospitalier Universitaire de Martinique · MQClatterbridge Cancer Centre NHS Foundation Trust · GBHospital Universitari Arnau de Vilanova · ESHospital Universitari Sant Joan de Reus · ESIPO Porto · PTKantonsspital Graubünden · CHMcGill University · CAOspedale Papa Giovanni XXIII · ITUniversidad Fernando Pessoa Canarias · ESUniversiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlder cancer patients with locally advanced or metastatic disease may benefit from chemotherapy alone or combined with radiotherapy. However, chemotherapy is often omitted either because of physician bias or because of its underlying comorbidity, thus compromising their survival. The coronavirus disease 19 (COVID-19) pandemic is compounding this issue because of the fear of immunosuppression induced by chemotherapy on the elderly which makes them more vulnerable to the virus. SUMMARY: Immunotherapy has less effect on the patient bone marrow compared to chemotherapy. The potential synergy between radiotherapy and immunotherapy may improve local control and survival for older patients with selected cancer. Preliminary data are encouraging because of better survival and local control in diseases which are traditionally resistant to radiotherapy and chemotherapy such as melanoma and renal cell carcinoma. Key Message: We propose a new paradigm combining immunotherapy at a reduced dose and/or extended dosing intervals and hypofractionated radiotherapy for older patients with selected cancer which needs to be tested in future clinical trials.

Indexed as

AgedBone MarrowCombined Modality TherapyCOVID-19HumansImmunotherapyNeoplasmsCancer patientsCOVID-19ImmunotherapyOlder patientsRadiotherapy

Identifiers

PMID33784693
PMCPMC8089416
OpenAlexW3140185967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.