ArticleJournal of biomechanics2021
Refining a numerical model for device-induced thrombosis and investigating the effects of non-Newtonian blood models.
Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- An Optimized Multi-Stage Drainage Cannula Design for Venoarterial Extracorporeal Membrane Oxygenation.Artificial organs · 2026Article
- Fluid Dynamic and in Vitro Blood Study to Understand Catheter-Related Thrombosis.Cardiovascular engineering and technology · 2025Article
- Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction.Annals of biomedical engineering · 2024Article
- A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth.Biomechanics and modeling in mechanobiology · 2024Article
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- Clot embolization studies and computational framework for embolization in a canonical tube model.Scientific reports · 2023Article
- von Willebrand factor unfolding mediates platelet deposition in a model of high-shear thrombosis.Biophysical journal · 2022Article
- Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.International journal for numerical methods in biomedical engineering · 2022Article
- Computational Prediction of Thrombosis in Food and Drug Administration's Benchmark Nozzle.Frontiers in physiology · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Thrombosis is one of the main causes of failure in device implantation. Computational thrombosis simulation is a convenient approach to evaluate the risk of thrombosis for a device. However, thrombosis is a complicated process involving multiple species and reactions. Application of a macroscopic, single-scale computational model for device-induced thrombosis is a cost-effective approach. The current study has refined an existing thrombosis model, which simulated thrombosis by tracing four species in blood: non-activated platelets, activated platelets, surface adherent platelets, and ADP. Platelets are activated mechanically by shear stress, and chemically by ADP. Platelet adhesion occurs on surfaces with low wall shear stress with platelet aggregation inhibited in regions of high shear stress. The study improves the existing thrombosis model by: 1) Modifying the chemical platelet activation function so that ADP activates platelets; 2) Modifying the function describing thrombus deposition and growth to distinguish between thrombus deposition on wall surfaces and thrombus growth on existing thrombus surfaces; 3) Modifying the thrombus breakdown function to allow for thrombus breakdown by shear stress; 4) Modeling blood flow as non-Newtonian. The results show that the inclusion of ADP and the use of a non-Newtonian model improve agreement with experimental data.
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