Evidence map›Paper›PMID 33784491›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.

Konstantin Tsoyi, Xiaoliang Liang, Giulia De Rossi, Stefan W Ryter, Kevin Xiong, Sarah G Chu, Xiaoli Liu, Bonna Ith, Lindsay J Celada, Freddy Romero and 8 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. zDHHC21 loss of function activates lung fibroblasts by regulating PTEN palmitoylation.American journal of respiratory cell and molecular biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Konstantin TsoyiSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Xiaoliang LiangSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Giulia De RossiWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Stefan W RyterDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York.
Kevin XiongDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Sarah G ChuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Xiaoli LiuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Bonna IthDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Lindsay J CeladaSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Freddy RomeroSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Matthew J RobertsonSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Anthony J EspositoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Sergio PoliDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Souheil El-ChemalyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Mark A PerrellaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
YuanYuan ShiSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
James WhitefordWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Ivan O RosasSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Brigham and Women's Hospital · USBaylor College of Medicine · USQueen Mary University of London · GBBeijing University of Chinese Medicine · CNCornell University · US

Funding

Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SILVERMAN, EDWIN K · 2013 to 2025
$24.9M
RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Antifibrotic effects of Syndecan-2 and CD148 in Rheumatoid Arthritis Interstitial Lung DiseaseK01AR074558 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI TSOYI, KONSTANTIN · 2020 to 2024
$655k
PAD4 Contributes to the Profibrotic Phenotype of Fibroblasts from Patients with IPF and Promotes Lung FibrosisF32HL151132 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ESPOSITO, ANTHONY JOSEPH · 2020 to 2021
$103k
NHLBI NIH HHS F32 HL151132NHLBI NIH HHS L30 HL149048NHLBI NIH HHS P01 HL114501NHLBI NIH HHS T32 HL007633NIAMS NIH HHS K01 AR074558
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibiotics, AntineoplasticAutophagyBleomycinDisease Models, AnimalFibroblastsHumansIdiopathic Pulmonary FibrosisIn Vitro TechniquesLungMiceMice, KnockoutNF-kappa BPeptide FragmentsPhenotypePhosphatidylinositol 3-KinasesAntibiotics, AntineoplasticBleomycinNF-kappa BPeptide FragmentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTPRJ protein, humanPtprj protein, mouseReceptor-Like Protein Tyrosine Phosphatases, Class 3Syndecan-2TOR Serine-Threonine KinasesCD148fibroblastidiopathic pulmonary fibrosisnuclear factor-kappa-Bsyndecan-2

Identifiers

PMID33784491
PMCPMC8513593
OpenAlexW3143179777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.