ArticlePloS one2021
High prevalence of extrapulmonary tuberculosis in dairy farms: Evidence for possible gastrointestinal transmission.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Global prevalence and risk factors of bovine tuberculosis in cattle: a systematic review and meta-analysis.Frontiers in veterinary science · 2026Pooled it
- An Examination of Gross Lesions Associated with Bovine Tuberculosis in the U.S.Pathogens (Basel, Switzerland) · 2026Article
- Apparent prevalence, lesion distribution and risk factors of bovine tuberculosis in cattle slaughtered at the Shashemene and Arsi Negelle municipal abattoirs, Ethiopia.One health (Amsterdam, Netherlands) · 2025Article
- Sero-Prevalence and Molecular Detection of Mycobacterium bovis in Cattle at Sylhet Division of Bangladesh.Veterinary medicine and science · 2025Article
- Article
- Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization.Veterinary research communications · 2025Article
- A one health-focused literature review on bovine and zoonotic tuberculosis in Pakistan from the past two decades: challenges and way forward for control.One health (Amsterdam, Netherlands) · 2024Review
- Development and evaluation of a triplex droplet digital PCR method for differentiation ofFrontiers in microbiology · 2024Article
- Will we ever eradicate animal tuberculosis?Irish veterinary journal · 2023Article
- Article
- Vaccination Strategies in a Potential Use of the Vaccine against Bovine Tuberculosis in Infected Herds.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine tuberculosis (bTB) caused by Mycobacterium bovis (M. bovis) represents one of major zoonotic diseases among cattle, it also affects the health of human, other domestic animals and wild life populations. Inhalation of infected aerosol droplets is considered as the most frequent route of the infection. This study aims to investigate the current forms of tuberculosis in cattle and identify the possible transmission modes in dairy farms of China. 13,345 cows from eight dairy farms in three provinces were comprehensively diagnosed by a multitude of assays, including SIT, CIT, IFN-γ assay and ELISA. It has been indicated that advanced infection of bTB was found in 752 (5.64%) cattle, suggesting a high prevalence of tuberculosis in these dairy farms. In the necropsy examination of 151 positive cattle, typical bTB lesions were observed in 131 cattle (86.75%), of which, notably, 90.84% lesions appeared in liver, spleen, mesenteric lymph nodes, mammary lymph nodes and other organs, taking up a large proportion among cattle with advanced bTB infection. 71.26% extrapulmonary tuberculosis (EPTB) was related to gastrointestinal system. M. bovis nucleic acid was further found in milk and feces samples and M. bovis was even isolated from milk samples. Phylogenetic analysis based on whole genome sequencing unraveled that six isolates were closely related to M. bovis AF2122/97 originated from UK, whereas four isolates shared close relation to M. bovis 30 from China, respectively. Our data demonstrate that the increase of EPTB transmitted by digestive tract is implicated in the current high prevalence rate of bTB in China, which also provides leads for bTB control in other countries with high prevalence of bTB in the future.
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