Evidence map›Paper›PMID 33784027›Full record

ArticleBrain and behavior2021

Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder.

Chunxin Liu, Hui Xiao, Xiayin Zhang, Yipeng Zhao, Rui Li, Xiaonan Zhong, Yuge Wang, Yaqing Shu, Yanyu Chang, Jingqi Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Chunxin LiuDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hui XiaoZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiayin ZhangZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yipeng ZhaoDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Rui LiDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaonan ZhongDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yuge WangDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yaqing ShuDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0003-1017-2554
Yanyu ChangDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-3226-1008
Jingqi WangDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Caixia LiSchool of Mathematics, Sun Yat-sen University, Guangzhou, China.
Haotian LinZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Wei QiuDepartment of Neurology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-0880-958X
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity.

methodsPatients with MS (n = 83) and AQP4-IgG-seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform layer (GC-IPL) thickness, macular vessel density (VD), and perfusion density (PD) in the superficial capillary plexus. Diagnostic accuracy was assessed using the area under the receiver operating characteristics curve.

resultsCompared with patients with MS, those with NMOSD had a significantly smaller average thickness of the pRNFL and GC-IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p < .001; 68.0 [56.0; 81.0] μm, versus 74.5 [64.2; 81.0] μm, p < .001) and significantly smaller whole VD and PD areas (15.6 [12.6; 17.0] mm

conclusionsOCT angiography reveals different structural and microvascular retinal changes in MS and AQP4-IgG-seropositive NMOSD. These combined structural and microvascular parameters might be promising biomarkers for disease diagnosis.

Indexed as

Multiple SclerosisNeuromyelitis OpticaAngiographyHumansImmunoglobulin GTomography, Optical CoherenceImmunoglobulin Gmultiple sclerosisneuromyelitis optica spectrum disorderoptical coherence tomography angiography

Identifiers

PMID33784027
PMCPMC8119797
OpenAlexW3146579389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.