Evidence map›Paper›PMID 33783931›Full record

ArticleAging cell2021

Mesenchymal stem cell-conditioned medium attenuates the retinal pathology in amyloid-β-induced rat model of Alzheimer's disease: Underlying mechanisms.

Shu-Chun Kuo, Chung-Ching Chio, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shu-Chun KuoDepartment of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.
Chung-Ching ChioDivision of Neurosurgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Chao-Hung YehDepartment of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan.
Jui-Ti MaDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Wen-Pin LiuDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Mao-Tsun LinDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Kao-Chang LinDepartment of Holistic Care, Chi Mei Medical Center, Tainan, Taiwan.
Ching-Ping ChangDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.ORCID 0000-0003-0890-9414
Chi Mei Medical Center · TWChung Hwa University of Medical Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid-beta (Aβ) oligomer is known to contribute to the pathophysiology of age-related macular degeneration. Herein, we aimed to elucidate the in vivo and in vitro effects of Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsApoptosisbeta CateninCell HypoxiaCell LineCulture Media, ConditionedDisease Models, AnimalHumansLearningMesenchymal Stem CellsPeptide FragmentsRatsRetinaRetinal DegenerationAmyloid beta-Peptidesamyloid beta-protein (1-42)beta CateninCulture Media, ConditionedPeptide FragmentsTight Junction ProteinsAlzheimer's diseaseamyloid-betaretina pigment epitheliumsecretomestem cell

Identifiers

PMID33783931
PMCPMC8135003
OpenAlexW3150233796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.