Evidence map›Paper›PMID 33783919›Full record

ReviewCancer science2021

Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.

Haruna Takeda, Nancy A Jenkins, Neal G Copeland

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Erratum.Cancer science · 2021
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Haruna TakedaLaboratory of Molecular Genetics, National Cancer Center Research Institute, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1643-2524
Nancy A JenkinsLaboratory of Molecular Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Neal G CopelandGenetics Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Grant-in-Aid for Scientific Research 20H03522MSD Foundation
6 · The paper itself

Abstract

Cancer genome sequencing studies have identified driver genes for a variety of different cancers and helped to understand the genetic landscape of human cancer. It is still challenging, however, to identify cancer driver genes with confidence simply from genetic data alone. In vivo forward genetic screens using Sleeping Beauty (SB) transposon mutagenesis provides another powerful genetic tool for identifying candidate cancer driver genes in wild-type and sensitized mouse tumors. By comparing cancer driver genes identified in human and mouse tumors, cancer driver genes can be identified with additional confidence based upon comparative oncogenomics. This review describes how SB mutagenesis works in mice and focuses on studies that have identified cancer driver genes in the mouse gastrointestinal tract.

Indexed as

DNA Transposable ElementsGenes, NeoplasmAnimalsDisease ProgressionDrug Resistance, NeoplasmGastrointestinal NeoplasmsGenetic Predisposition to DiseaseGenetic TestingHumansMiceMutagenesis, InsertionalNeoplasmsDNA Transposable Elementscancer driver genescolorectal cancermouse modelscreeningSleeping Beauty transposon mutagenesis

Identifiers

PMID33783919
PMCPMC8177796
OpenAlexW3150519244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.