Evidence map›Paper›PMID 33783850›Full record

Observational studyJournal of medical virology2021

Viral community acquired pneumonia at the emergency department: Report from the pre COVID-19 age.

Ornella Spagnolello, Alessandra Pierangeli, Maria Civita Cedrone, Valentina Di Biagio, Massimo Gentile, Annalisa Leonardi, Camilla Valeriano, Giuseppe Pietro Innocenti, Letizia Santinelli, Cristian Borrazzo and 7 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Ornella SpagnolelloDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy.ORCID http://orcid.org/0000-0002-6201-389X
Alessandra PierangeliLaboratory of Virology, Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy.
Maria Civita CedroneEmergency Department, University of Rome Sapienza, Rome, Italy.
Valentina Di BiagioEmergency Department, University of Rome Sapienza, Rome, Italy.
Massimo GentileLaboratory of Virology, Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy.
Annalisa LeonardiEmergency Department, University of Rome Sapienza, Rome, Italy.
Camilla ValerianoEmergency Department, University of Rome Sapienza, Rome, Italy.
Giuseppe Pietro InnocentiDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy.
Letizia SantinelliDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy.
Cristian BorrazzoDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy.
Alessandro RussoDepartment of Public Health and Infectious Diseases, University of Pisa, Pisa, Italy.
Giuseppe OlivetoLaboratory of Virology, Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy.
Agnese ViscidoLaboratory of Virology, Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy.
Massimo CiccozziUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.ORCID http://orcid.org/0000-0003-3866-9239
Giuliano BertazzoniEmergency Department, University of Rome Sapienza, Rome, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy.ORCID http://orcid.org/0000-0001-5921-3180
Sapienza University of Rome · ITDepartment of Public Health · MMUniversità Campus Bio-Medico · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of viruses in community acquired pneumonia (CAP) has been largely underestimated in the pre-coronavirus disease 2019 age. However, during flu seasonal early identification of viral infection in CAP is crucial to guide treatment and in-hospital management. Though recommended, the routine use of nasopharyngeal swab (NPS) to detect viral infection has been poorly scaled-up, especially in the emergency department (ED). This study sought to assess the prevalence and associated clinical outcomes of viral infections in patients with CAP during peak flu season. In this retrospective, observational study adults presenting at the ED of our hospital (Rome, Italy) with CAP from January 15th to February 22th, 2019 were enrolled. Each patient was tested on admission with Influenza rapid test and real time multiplex assay. Seventy five consecutive patients were enrolled. 30.7% (n = 23) tested positive for viral infection. Of these, 52.1% (n = 12) were H1N1/FluA. 10 patients had multiple virus co-infections. CAP with viral infection did not differ for any demographic, clinic and laboratory features by the exception of CCI and CURB-65. All intra-ED deaths and mechanical ventilations were recorded among CAP with viral infection. Testing only patients with CURB-65 score ≥2, 10 out of 12 cases of H1N1/FluA would have been detected saving up to 40% tests. Viral infection occurred in one-third of CAP during flu seasonal peak 2019. Since not otherwise distinguishable, NPS is so far the only reliable mean to identify CAP with viral infection. Testing only patients with moderate/severe CAP significantly minimize the number of tests.

Indexed as

AgedCoinfectionCommunity-Acquired InfectionsCOVID-19Emergency Service, HospitalFemaleHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanItalyMalePneumoniaPrevalenceRetrospective StudiesSARS-CoV-2community acquired pneumoniaemergency departmentpublic healthviral infection

Identifiers

PMID33783850
PMCPMC8250557
OpenAlexW3141295064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.