Evidence map›Paper›PMID 33783606›Full record

ArticleCell and tissue research2021

Essential roles of matrix metalloproteinases in axolotl digit regeneration.

Tianyue Huang, Lingling Zuo, Katarzyna S Walczyńska, Mengying Zhu, Yujun Liang

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Characterizing the lens regeneration process in Pleurodeles waltl.Differentiation; research in biological diversity
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tianyue Huang *College of Marine Life Science, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Lingling Zuo *College of Marine Life Science, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Katarzyna S WalczyńskaCollege of Marine Life Science, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Mengying ZhuCollege of Marine Life Science, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Yujun LiangCollege of Marine Life Science, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China. liangyujun@ouc.edu.cn.ORCID http://orcid.org/0000-0002-1253-8364
Ocean University of China · CN

Funding

National Science and Technology Program during the Twelfth Five-year Plan Period (CN) 2017ASTP01Natural Science Foundation of Shandong of China ZR2012CM030Support Program for Longyuan Youth and Fundamental Research Funds for the Universities of Gansu Province (CN) 201822018
6 · The paper itself

Abstract

Among vertebrates, urodele amphibians possess a unique ability to regenerate various body parts including limbs. However, reports of their digit regeneration remain scarce, especially information about the related genes. In this study, it was evident that matrix metalloproteinases (mmps) including mmp9, mmp3/10a, and mmp3/10b, which play a crucial role in tissue remodeling, are highly expressed during early stages of digit regeneration in axolotl. Using in situ hybridization, we revealed that wound epidermis and blastema are two major origins of the MMPs during the regeneration process. Additionally, we found that the inhibition of MMPs with GM6001 (a wide-spectrum inhibitor of MMPs) in vivo after amputation disturbed normal digit regeneration process and resulted in malformed regenerates. Furthermore, inhibition of MMPs hindered blastema formation and decreased cell apoptosis at early stages in the digit regenerates. All these points suggest that MMPs are required for digit regeneration, as they play a significant role in the regulation of blastema formation.

Indexed as

Ambystoma mexicanumAnimalsDisease Models, AnimalExtremitiesMatrix MetalloproteinasesRegenerationMatrix MetalloproteinasesAmbystoma mexicanumAxolotlBlastemaDigit regenerationMatrix metalloproteinases

Identifiers

PMID33783606
OpenAlexW3144822929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.