ArticleEuropean radiology2021
The presence of contrast agent increases organ radiation dose in contrast-enhanced CT.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Renal protection CT protocol using low-dose and low-concentration iodine contrast medium in at-risk patients of HCC and with chronic kidney disease: a randomized controlled non-inferiority trial.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Trial
- Quantifying Radiation Effects of Iodinated Contrast Media in Pediatric CT Using DNA Damage Biomarkers.International journal of molecular sciences · 2026Article
- Can an Unenhanced Reduced-Dose ECG-Gated CT of the Aorta Replace an ECG-Gated CT-Angiography for Diameter Follow-Up of the Ascending Aorta?Journal of cardiovascular development and disease · 2026Article
- Comparison of deep learning reconstruction algorithms to improve image quality of dual-energy carotid CT angiography under dual-low scan.Neuroradiology · 2026Article
- Optimizing coronary CT angiography with spectral dual-layer CT: motion-compensated virtual monoenergetic imaging achieves 50% contrast dose reduction in a phantom study.The international journal of cardiovascular imaging · 2026Article
- Double low-dose abdominopelvic CT for acute appendicitis: early exploratory analysis on image quality and diagnostic performance.Abdominal radiology (New York) · 2025Article
- Iodinated contrast media (ICM)-induced thyroid dysfunction: a review of potential mechanisms and clinical management.Clinical and experimental medicine · 2025Review
- CT-based synthetic contrast-enhanced dual-energy CT generation using conditional denoising diffusion probabilistic model.Physics in medicine and biology · 2024Article
- Application of simple ultrasound Doppler hemodynamic parameters in the diagnosis of severe renal artery stenosis in routine clinical practice.Quantitative imaging in medicine and surgery · 2023Article
- Presentation of Organ Dose and Effective Dose Conversion Factors in Dual-Energy Computed Tomography: A Monte Carlo Simulation Study.Journal of biomedical physics & engineering · 2023Article
- Abdominal virtual non-contrast images derived from energy spectrum CT to evaluate chemotherapy-related fatty liver disease.Quantitative imaging in medicine and surgery · 2023Article
- The evolving role of radiation therapy as treatment for liver metastases.Journal of the National Cancer Center · 2022Review
- 4DCT Scanning Technique for Primary Hyperparathyroidism: A Scoping Review.Radiology research and practice · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesRoutine dosimetry calculations do not account for the presence of iodine in organs and tissues during CT acquisition. This study aims to investigate the impact of contrast agent (CA) on radiation dose.
methodsFirst, relation between absorbed radiation dose and iodine concentrations was investigated using a cylindrical water phantom with iodine-saline dilution insertions. Subsequently, a retrospective study on abdominal dual-energy CT (DECT) patient data was performed to assess the increase of the local absorbed radiation dose compared to a non-contrast scan. Absorbed doses were estimated with Monte Carlo simulations using the individual CT voxel data of phantom and patients. Further, organ segmentations were performed to obtain the dose in liver, liver parenchyma, left kidney, right kidney, aorta, and spleen.
resultsIn the phantom study, a linear relation was observed between the radiation dose normalized by computed tomography dose index (CTDI) and CA concentrations I
conclusionsCompared to a non-contrast scan, the organ doses increase by 30% in contrast-enhanced abdominal CT. This study suggests considering CA in dosimetry calculations, epidemiological studies, and organ dose estimations while developing new CT protocols. KEY POINTS: • The presence of contrast media increases radiation absorption in CT, and this increase is related to the iodine content in the organs. • The increased radiation absorption due to contrast media can lead to an average 30% increase in absorbed organ dose. • Iodine should be considered in CT radiation safety studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.