Evidence map›Paper›PMID 33783321›Full record

ArticleEpigenetics2022

Identification of a foetal epigenetic compartment in adult human kidney.

John K Wiencke, Ze Zhang, Devin C Koestler, Lucas A Salas, Annette M Molinaro, Brock C Christensen, Karl T Kelsey

Abstract read
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John K WienckeDepartment of Neurological Surgery, Institute for Human Genetics, University of California, San Francisco, CA, USA.
Ze ZhangDepartment of Epidemiology, Department of Pathology and Laboratory Medicine, Brown University School of Public Health, Providence, RI, USA.
Devin C KoestlerDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0002-0598-0146
Lucas A SalasDepartment of Epidemiology, Department of Molecular and Systems Biology, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA.ORCID 0000-0002-2279-4097
Annette M MolinaroDepartment of Neurological Surgery, Institute for Human Genetics, University of California, San Francisco, CA, USA.
Brock C ChristensenDepartment of Epidemiology, Department of Molecular and Systems Biology, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA.ORCID 0000-0003-3022-426X
Karl T KelseyDepartment of Epidemiology, Department of Pathology and Laboratory Medicine, Brown University School of Public Health, Providence, RI, USA.

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
Immune epigenetic biomarkers of survival in glioma epidemiologyR01CA207360 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2017 to 2021
$3.8M
(PQ3) Immune epigenetic biomarkers of bladder cancer outcomesR01CA216265 · NCI · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2017 to 2021
$2.9M
MicroRNA related genetic variation and head and neck cancerR01DE022772 · NIDCR · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2016
$2.7M
Prospective immune profiling using methylation markers and pancreatic cancer riskR01CA207110 · NCI · TUFTS UNIVERSITY BOSTON · PI KELSEY, KARL TIMOTHY, MICHAUD, DOMINIQUE S. · 2016 to 2018
$2.1M
NCI NIH HHS P30 CA168524NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA207110NCI NIH HHS R01 CA207360NCI NIH HHS R01 CA216265NIDCR NIH HHS R01 DE022772NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM104416NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

The mammalian kidney has extensive repair capacity; however, identifying adult renal stem cells has proven elusive. We applied an epigenetic marker of foetal cell origin (FCO) in diverse human tissues as a probe for developmental cell persistence, finding a 5.4-fold greater FCO proportion in kidney. Normal kidney FCO proportions averaged 49% with extensive interindividual variation. FCO proportions were significantly negatively correlated with immune-related gene expression and positively correlated with genes expressed in the renal medulla, including those involved in renal organogenesis (e.g.,

Indexed as

DNA MethylationGenes, HomeoboxAnimalsEpigenesis, GeneticFetusHomeodomain ProteinsHumansKidneyMammalsMiceRatsHomeodomain ProteinsHOXB7 protein, humanDNA methylationepigeneticsfoetal stem cellsKidneystem cell niche

Identifiers

PMID33783321
PMCPMC8920245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.