Trial reportJournal of geriatric psychiatry and neurology2022
Computerized Cognitive Training in Amnestic Mild Cognitive Impairment: A Randomized Clinical Trial.
Trial report in Journal of geriatric psychiatry and neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The effect of cognitive training on domains of attention in older adults with mild cognitive impairment and mild dementia: A meta-analysis of randomised controlled trials.Journal of global health · 2023Pooled it
- Effectiveness of computer-based interventions for community-dwelling people with cognitive decline: a systematic review with meta-analyses.BMC geriatrics · 2023Pooled it
- [Long-term maintenance of the emotional benefits of cognitive stimulation in early-stage cognitive impairment].Anales del sistema sanitario de Navarra · 2026Trial
- Preliminary effects of mobile computerized cognitive training in adults with mild cognitive impairment: interim analysis of a randomized controlled trial.BMC psychology · 2025Trial
- More than Just a Game: A Longitudinal Pilot Study on the Outcome Effects of Home-Based Digital Cognitive Rehabilitation in Outpatients with Mild Cognitive Impairment.Brain sciences · 2026Article
- Navigating Aging with Technology: A Scoping Review of Digital Interventions Addressing Intrinsic Capacity Decline in Older Adults.Healthcare (Basel, Switzerland) · 2026Review
- Article
- Digital Health Technologies Applied in Patients With Early Cognitive Change: Scoping Review.Journal of medical Internet research · 2025Article
- The Effects of Computerized Cognitive Training via Tablet and Computer Platforms on Cognitive Function in Patients with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2025Review
- Targeting Executive Function and Language Impairments with tACS Combined with Behavioral Intervention in Primary Progressive Aphasia: A Case-Series, Pilot Investigation.Brain sciences · 2025Article
- Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes.Frontiers in endocrinology · 2025Review
- The Efficacy of Cognitive Training on Neuropsychological Outcomes in Mild Cognitive Impairment: A Meta-Analysis.Brain sciences · 2023Review
- Cognitive Interventions for Neurodegenerative Disease.Current neurology and neuroscience reports · 2023Review
- Predicting daily functioning with the modified Telephone Interview for Cognitive Status.Aging clinical and experimental research · 2022Article
- Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveComputerized cognitive training has been successful in healthy older adults, but its efficacy has been mixed in patients with amnestic Mild Cognitive Impairment (MCI).
methodsIn a randomized, placebo-controlled, double-blind, parallel clinical trial, we examined the short- and long-term efficacy of a brain-plasticity computerized cognitive training in 113 participants with amnestic MCI.
resultsImmediately after 40-hours of training, participants in the active control group who played computer games performed better than those in the experimental group on the primary cognitive outcome (p = 0.02), which was an auditory memory/attention composite score. There were no group differences on 2 secondary outcomes (global cognitive composite and rating of daily functioning). After 1 year, there was no difference between the 2 groups on primary or secondary outcomes. No adverse events were noted.
conclusionsAlthough the experimental cognitive training program did not improve outcomes in those with MCI, the short-term effects of the control group should not be dismissed, which may alter treatment recommendations for these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.