Evidence map›Paper›PMID 33783202›Full record

ArticleJournal of the American Chemical Society2021

3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs.

Jihyun Kim, Mihajlo Novakovic, Sundaresan Jayanthi, Adonis Lupulescu, Eriks Kupce, J Tassilo Grün, Klara Mertinkus, Andreas Oxenfarth, Christian Richter, Robbin Schnieders and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Identifying and Overcoming Artifacts inJournal of the American Chemical Society · 2023
    Article
  3. Review
  4. The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-LabileChemphyschem : a European journal of chemical physics and physical chemistry · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Jihyun KimDepartment of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Mihajlo NovakovicDepartment of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Sundaresan JayanthiDepartment of Physics, Indian Institute of Space Science and Technology, Valiamala, Thiruvananthapuram 695 547, Kerala, India.ORCID 0000-0003-3957-1022
Adonis LupulescuAleea Nicolae Titulescu nr. 8, Turda, 407405 Judeţul Cluj, Romania.
Eriks KupceBruker Ltd, Banner Lane, Coventry CV4 9GH, United Kingdom.ORCID 0000-0002-2366-0269
J Tassilo GrünInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.
Klara MertinkusInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.
Andreas OxenfarthInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.
Christian RichterInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.
Robbin SchniedersInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.
Julia Wirmer-BartoschekInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.
Harald SchwalbeInstitute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University, D-60438 Frankfurt/Main, Germany.ORCID 0000-0001-5693-7909
Lucio FrydmanDepartment of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0001-8208-3521
Goethe University Frankfurt · DEWeizmann Institute of Science · ILBruker (United Kingdom) · GBIndian Institute of Space Science and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidimensional NOESY experiments targeting correlations between exchangeable imino and amino protons provide valuable information about base pairing in nucleic acids. It has been recently shown that the sensitivity of homonuclear correlations involving RNA's labile imino protons can be significantly enhanced, by exploiting the repolarization brought about by solvent exchanges. Homonuclear correlations, however, are of limited spectral resolution, and usually incapable of tackling relatively large homopolymers with repeating structures like RNAs. This study presents a heteronuclear-resolved version of those NOESY experiments, in which magnetization transfers between the aqueous solvent and the nucleic acid protons are controlled by selecting specific chemical shift combinations of a coupled

Indexed as

Magnetic PhenomenaMagnetic Resonance SpectroscopyRNA, ViralSARS-CoV-2TemperatureRNA, Viral

Identifiers

PMID33783202
PMCPMC8154514
OpenAlexW3139686530

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.