Observational studyColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2021
The Pulmonary Metastasectomy in Colorectal Cancer cohort study: Analysis of case selection, risk factors and survival in a prospective observational study of 512 patients.
Observational study in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) randomized controlled trial: a systematic review of published responses.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Pooled it
- Trial
- The full cohort of 512 patients and the nested controlled trial in 93 patients in the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) study raise doubts about the effective size at present claimed.Journal of cardiothoracic surgery · 2022Trial
- The Jury Remains Out: The Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) Study Highlights the Need for Stringent Trials Investigating the Efficacy of Surgical Intervention.Annals of surgical oncology · 2026Article
- Article
- Prevalence and Prognostic Value of Mediastinal Lymph Node Dissection in Pulmonary Metastasectomy: A Retrospective Single-Center Analysis.Thoracic cancer · 2026Article
- Importance of the ratio of surgical margin to nodule size in pulmonary metastasectomy for colorectal carcinoma.General thoracic and cardiovascular surgery · 2026Article
- Comment on Pang et al. Ablative Techniques for Lung Metastases: Patient Selection and Outcomes Following Treatment with Stereotactic Radiotherapy or Radiofrequency Ablation.Current oncology (Toronto, Ont.) · 2025Article
- The Ugly: Metastatic Colon Cancer-Surgical Options.Clinics in colon and rectal surgery · 2025Review
- Effects of location of primary tumor on survival after pulmonary metastasectomy for colorectal cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2025Article
- Decoding colorectal cancer lung metastasis: a global research odyssey.Frontiers in oncology · 2025Article
- Comments on Ambrogi et al. Lung Metastasectomy: Where Do We Stand? Results from an Italian Multicentric Prospective Database.Journal of clinical medicine · 2024Article
- A Retrospective Analysis of Real-Life Management of Colorectal Cancer Lung-Limited Metastases Treated with Surgery: Outcomes and Prognostic Factors.Journal of clinical medicine · 2024Article
- The belief in clinical benefit from lung metastasectomy in colorectal cancer is questioned by the PulMiCC study and its nested randomised controlled trial.Langenbeck's archives of surgery · 2024Article
- A prospective multicentre cohort study of colorectal lung metastasectomy with a nested randomized controlled trial: the key points from the pulmonary metastasectomy in colorectal cancer study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Article
- Article
- Long-term outcomes and early recurrence after resection for metachronous pulmonary metastases from colorectal cancer.Langenbeck's archives of surgery · 2023Article
- Observations on local interventions for colorectal cancer metastases to liver and lung.Irish journal of medical science · 2023Article
- Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases.Journal of gastrointestinal cancer · 2023Article
- Colorectal Pulmonary Metastases: Pulmonary Metastasectomy or Stereotactic Radiotherapy?Cancers · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
aimWe wanted to examine survival in patients with resected colorectal cancer (CRC) whose lung metastases are or are not resected.
methodsTeams participating in the study of Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) identified potential candidates for lung metastasectomy and invited their consent to join Stage 1. Baseline data related to CRC and fitness for surgery were collected. Eligible patients were invited to consent for randomization in the PulMiCC randomized controlled trial (Stage 2). Sites were provided with case report forms for non-randomized patients to record adverse events and death at any time. They were all reviewed at 1 year. Baseline and survival data were analysed for the full cohort.
resultsTwenty-five clinical sites recruited 512 patients from October 2010 to January 2017. Data collection closed in October 2020. Before analysis, 28 patients with non-CRC lung lesions were excluded and three had withdrawn consent leaving 481. The date of death was known for 292 patients, 136 were alive in 2020 and 53 at earlier time points. Baseline factors and 5-year survival were analysed in three strata: 128 non-randomized patients did not have metastasectomy; 263 had elective metastasectomy; 90 were from the randomized trial. The proportions of solitary metastases for electively operated and non-operated patients were 69% and 35%. Their respective 5-year survivals were 47% and 22%.
conclusionSurvival without metastasectomy was greater than widely presumed. Difference in survival appeared to be largely related to selection. No inference can be drawn about the effect of metastasectomy on survival in this observational study.
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