ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2022
Knee joint unloading and daily physical activity associate with cartilage T2 relaxation times 1 month after ACL injury.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Differences in gait biomechanics in the first year after anterior cruciate ligament reconstruction: A systematic review.Clinical biomechanics (Bristol, Avon) · 2026Pooled it
- Are Altered Knee Joint Biomechanics Associated with Future Post-Traumatic Osteoarthritis Outcomes? A Systematic Review and Meta-Analysis of Longitudinal Studies.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Human synovial fluid interleukin-6, but not type II collagen breakdown, positively correlated with pain after anterior cruciate ligament injury and reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Trial
- Surgical treatments of bone marrow lesions.Journal of experimental orthopaedics · 2026Review
- Changes in Muscle Volume Asymmetries Among Lower Extremity Muscles From Baseline Through 12 Months After Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Autograft.Orthopaedic journal of sports medicine · 2026Article
- Hip Joint Loading During Walking Is Associated With Cartilage Defect Severity in Young Adult Football Players With Hip/Groin Pain.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Muscle performance but not biomechanics associate with second knee injury in a matched cohort of athletes who passed functional return-to-sport criteria after ACL reconstruction.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Quadriceps Strength and Movement Patterns in Patients After ACLR Who Pass a Clinic-Based Return-to-Sport Testing Battery.Orthopaedic journal of sports medicine · 2026Article
- Early Unloading After ACL Rupture and Prior to Surgical Restabilization in Mice Slows Post-Traumatic Osteoarthritis Progression.Cartilage · 2026Article
- Reliability of Semi-Automated Volumetric Quantification of Knee Effusion Using MRI After Acl Injury.The Iowa orthopaedic journal · 2026Observational
- Exploring Sprint Kinematics in American Football Athletes After Anterior Cruciate Ligament Reconstruction.Scandinavian journal of medicine & science in sports · 2026Article
- Conservative Management of Focal Chondral Lesions of the Knee and Ankle: Current Concepts.Cells · 2025Review
- Relationship between Changes in Physical Activity and Knee Health 18 Months after ACL Reconstruction.Medicine and science in sports and exercise · 2025Article
- The beneficial and detrimental effects of exercise and unloading on OA progression after anterior cruciate ligament injury.Connective tissue research · 2025Review
- Knee Loading Asymmetries During Descent and Ascent Phases of Squatting After ACL Reconstruction.Applied sciences (Basel, Switzerland) · 2025Article
- Investigating the Impact of Preoperative Kinesiophobia and Pain on Postoperative Gait Biomechanics Following Anterior Cruciate Ligament Injury.Orthopaedic journal of sports medicine · 2025Article
- Early Gait Biomechanics Linked to Daily Steps After Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2025Article
- Sedentary Behavior Patterns After ACL Reconstruction.International journal of exercise science · 2025Article
- Efficacy of a Squat Visual Biofeedback Program After ACL Reconstruction: Protocol for a Prospective, Parallel, Randomized Controlled Trial.International journal of sports physical therapy · 2025Article
- Peak vertical ground reaction force used to identify sub-groups of individuals with differing biomechanical gait profiles post-anterior cruciate ligament reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Osteoarthritis (OA) is prevalent after anterior cruciate ligament (ACL) injury, but mechanismsunderlying its development are poorly understood. The purpose of this study was to determine if gait biomechanics and daily physical activity (PA) associate with cartilage T2 relaxation times, a marker of collagen organization and water content, 1 month after ACL injury. Twenty-seven participants (15-35 years old) without chondral lesions completed magnetic resonance imaging, three-dimensional gait analysis, and 1 week of PA accelerometry. Interlimb differences and ratios were calculated for gait biomechanics and T2 relaxation times, respectively. Multiple linear regression models adjusted for age, sex, and concomitant meniscus injury were used to determine the association between gait biomechanics and PA with T2 relaxation times, respectively. Altered knee adduction moment (KAM) impulse, less knee flexion excursion (kEXC) and higher daily step counts accounted for 35.8%-65.8% of T2 relaxation time variation in the weightbearing and posterior cartilage of the medial and lateral compartment (all p ≤ .011). KAM impulse was the strongest factor for T2 relaxation times in all models (all p ≤ .001). Lower KAM impulse associated with longer T2 relaxation times in the injured medial compartment (β = -.720 to -.901) and shorter T2 relaxation in the lateral compartment (β = .713 to .956). At 1 month after ACL injury, altered KAM impulse, less kEXC, and higher PA associated with longer T2 relaxation times, which may indicate poorer cartilage health. Statement of Clinical Significance: Gait biomechanics and daily PA are modifiable targets that may improve cartilage health acutely after ACL injury and slow progression to OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.