Evidence map›Paper›PMID 33783027›Full record

ReviewScandinavian journal of immunology2021

Coronavirus infection: An immunologists' perspective.

Juan Bautista De Sanctis, Alexis Hipólito García, Dolores Moreno, Marián Hajduch

Open access · bronzeAbstract readReview
In one paragraph

Review in Scandinavian journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Coronavirus infection: An immunologists' perspective.Scandinavian journal of immunology · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Juan Bautista De SanctisInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID https://orcid.org/0000-0002-5480-4608
Alexis Hipólito GarcíaInstitute of Immunology, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela.ORCID https://orcid.org/0000-0002-2354-0160
Dolores MorenoChair of General Pathology and Pathophysiology, Faculty of Medicine, Central University of Venezuela, Caracas, Venezuela.ORCID https://orcid.org/0000-0002-6481-1377
Marián HajduchInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID https://orcid.org/0000-0002-4834-908X
Central University of Venezuela · VEInstitute of Molecular and Translational Medicine · CZ

Funding

Molecular, cellular, and clinical approach to healthy aging grant ENOCH CZ.02.1.01/0.0/0.0/16_019/0000868MTM
6 · The paper itself

Abstract

Coronavirus infections are frequent viral infections in several species. As soon as the severe acute respiratory syndrome (SARS) appeared in the early 2000s, most of the research focused on pulmonary disease. However, disorders in immune response and organ dysfunctions have been documented. Elderly individuals with comorbidities exhibit worse outcomes in all the coronavirus that cause SARS. Disease severity in SARS-CoV-2 infection is related to severe inflammation and tissue injury, and effective immune response against the virus is still under analysis. ACE2 receptor expression and polymorphism, age, gender and immune genetics are factors that also play an essential role in patients' clinical features and immune responses and have been partially discussed. The present report aims to review the physiopathology of SARS-CoV-2 infection and propose new research topics to understand the complex mechanisms of viral infection and viral clearance.

Indexed as

Angiotensin-Converting Enzyme 2BiomarkersCOVID-19Cytokine Release SyndromeCytokinesDisease SusceptibilityEnergy MetabolismHost-Pathogen InteractionsHumansImmunity, InnateInflammation MediatorsLymphocyte SubsetsReceptor, Angiotensin, Type 2Receptors, VirusSARS-CoV-2Virus ReplicationACE2 protein, humanAngiotensin-Converting Enzyme 2BiomarkersCytokinesInflammation MediatorsReceptor, Angiotensin, Type 2Receptors, Viruscomplementcoronaviruscytokine stormimmune responseinnate immune responsememory cellsSARS-CoV-2 infection

Identifiers

PMID33783027
PMCPMC8250184
OpenAlexW3147257818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.