Evidence map›Paper›PMID 33782857›Full record

ArticleJournal of cardiovascular translational research2022

Myocardial Injury Promotes Matrix Metalloproteinase-9 Activity in the Renal Cortex in Preclinical Models of Acute Myocardial Infarction.

Xiaoying Qiao, Shreyas Bhave, Lija Swain, Elric Zweck, Lara Reyelt, Paige Crowley, Shiva K Annamalai, Aditya Chennjorwala, Michele Esposito, Allen Razavi and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Xiaoying Qiao *Molecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Shreyas Bhave *Molecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Lija SwainMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Elric ZweckMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Lara ReyeltMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Paige CrowleyMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Shiva K AnnamalaiMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Aditya ChennjorwalaMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Michele EspositoMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Allen RazaviMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Sina ForoutanjaziMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Cody MachenMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Katherine ThayerMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Lena JordeMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Richard H KarasMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA.
Navin K KapurMolecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and The CardioVascular Center, Tufts Medical Center, 800 Washington Street Box # 80, Boston, MA, 02111, USA. Nkapur@tuftsmedicalcenter.org.ORCID 0000-0002-8302-6796
Tufts Medical Center · US

Funding

Mechanical Unloading and Delayed Reperfusion Promotes Myocardial Recovery after Acute Myocardial InfarctionR01HL139785 · NHLBI · TUFTS MEDICAL CENTER · PI KAPUR, NAVIN KUMAR · 2018 to 2021
$2.9M
Endoglin: A New Target of Therapy for Heart FailureR01HL133215 · NHLBI · TUFTS MEDICAL CENTER · PI KAPUR, NAVIN KUMAR · 2016 to 2020
$2.2M
NHLBI NIH HHS R01 HL133215NHLBI NIH HHS R01 HL139785
6 · The paper itself

Abstract

New mechanistic insight into how the kidney responds to cardiac injury during acute myocardial infarction (AMI) is required. We hypothesized that AMI promotes inflammation and matrix metalloproteinase-9 (MMP9) activity in the kidney and studied the effect of initiating an Impella CP or veno-arterial extracorporeal membrane oxygenation (VA-ECMO) before coronary reperfusion during AMI. Adult male swine were subjected to coronary occlusion and either reperfusion (ischemia-reperfusion; IR) or support with either Impella or VA-ECMO before reperfusion. IR and ECMO increased while Impella reduced levels of MMP-9 in the myocardial infarct zone, circulation, and renal cortex. Compared to IR, Impella reduced myocardial infarct size and urinary KIM-1 levels, but VA-ECMO did not. IR and VA-ECMO increased pro-fibrogenic signaling via transforming growth factor-beta and endoglin in the renal cortex, but Impella did not. These findings identify that AMI increases inflammatory activity in the kidney, which may be attenuated by Impella support.

Indexed as

Extracorporeal Membrane OxygenationHeart-Assist DevicesMyocardial InfarctionAnimalsMaleMatrix Metalloproteinase 9Shock, CardiogenicSwineMatrix Metalloproteinase 9Cardio-renalHemodynamicsKidney injuryMechanical supportMyocardial infarction

Identifiers

PMID33782857
PMCPMC8983528
OpenAlexW3143418398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.