ReviewHerzschrittmachertherapie & Elektrophysiologie2021
Arrhythmic risk during pregnancy and postpartum in patients with long QT syndrome.
Review in Herzschrittmachertherapie & Elektrophysiologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- A Heart Under Stress: Anaesthetic Strategy for a Pregnant Patient With Long QT Syndrome.Cureus · 2026Article
- Inhibitory effect of oestradiol on the cardiac KExperimental physiology · 2026Article
- Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance.American journal of physiology. Heart and circulatory physiology · 2025Article
- Exploring the mechanisms of sex-specific proarrhythmia in long QT syndrome through computational modeling.American journal of physiology. Heart and circulatory physiology · 2025Article
- Palpitations in puerperium-a self-recorded smart watch ECG gives the hint to hormone-induced ventricular arrhythmia: case report.European heart journal. Case reports · 2024Article
- Preventing and Treating Torsades de Pointes in the Mother, Fetus and Newborn in the Highest Risk Pregnancies with Inherited Arrhythmia Syndromes.Journal of clinical medicine · 2023Review
- Sex differences in long QT syndrome.Frontiers in cardiovascular medicine · 2023Review
- Biological Life-Stage and the Burden of Cardiac Events in Women With Congenital Long QT Syndrome.Circulation. Arrhythmia and electrophysiology · 2022Article
- [Arrhythmias in pregnancy].Herzschrittmachertherapie & Elektrophysiologie · 2021Article
- Prevalence and Risk Factors of QTc Prolongation During Pregnancy.Frontiers in cardiovascular medicine · 2021Article
- Mechanical QT and JT intervals by M-mode echocardiography: An extrapolation from the concurrent electrocardiographic tracings.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital long QT syndrome (LQTS) is a genetic disorder characterized by a prolonged QT interval in the surface electrocardiogram (ECG) that predisposes affected individuals to arrhythmic syncope, ventricular torsades-de-pointes, and sudden cardiac death at a young age. Investigations of large patient cohorts revealed sex-related differences in the LQTS phenotype. Adult women with LQTS are at higher risk for cardiac arrhythmias than are adult men with LQTS. Sex hormones are thought to play the primary role for these gender differences. Clinical experience and translational studies indicated that females with LQTS have a lower risk for cardiac arrhythmias during pregnancy and elevated risk in the postpartum period due to contrasting effects of estradiol and progesterone, as well as postpartum hormones on the action potential and arrhythmia substrate. However, this pro- or anti-arrhythmic potential of hormones varies depending on the underlying genotype, partly since sex hormones have distinct effects on different (affected) cardiac ion channels. Thus, a comprehensive evaluation of women with LQTS prior to and during pregnancy, during labor, and in the postpartum period with consideration of the patient's disease- and gene-specific risk factors is essential to providing precision management in this patient group. This review discusses the current understanding of hormonal influences in LQTS and provides practical guidance for the optimal management of LQTS patients during pregnancy, delivery, and the postpartum period.
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