Evidence map›Paper›PMID 33782741›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Malignant phyllodes tumour of the breast mimicking endometriosis.

Andrew H S Lee, Ulises Zanetto, Rachna Awasthi, Mei-Ju Hwang, Nur Diyana Md Nasir, Cedric Chuan Young Ng, Bin Tean Teh, Puay Hoon Tan

Abstract readCase Reports
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Morphological features of 52 cases of breast phyllodes tumours with local recurrence.Virchows Archiv : an international journal of pathology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew H S LeeHistopathology Department, Nottingham University Hospitals, City Hospital Campus, Nottingham, NG5 1PB, UK. andrew.lee@nuh.nhs.uk.ORCID http://orcid.org/0000-0003-2496-4050
Ulises ZanettoHistology Department, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Rachna AwasthiHistology Department, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Mei-Ju HwangBreast Unit, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Nur Diyana Md NasirDepartment of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
Cedric Chuan Young NgLaboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore.
Bin Tean TehLaboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore.
Puay Hoon TanDepartment of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. The excision also showed a fibroepithelial component with stromal overgrowth, frequent mitoses and invasive margin consistent with a malignant phyllodes tumour. KMT2D and SETD2 mutations were present in both the conventional phyllodes tumour and endometriosis-like areas and are also described in endometriosis raising interesting questions about these lesions. This unusual pattern is a potential diagnostic pitfall, so it is helpful to be aware of it.

Indexed as

Biomarkers, TumorBiopsy, Large-Core NeedleBreast NeoplasmsDiagnosis, DifferentialDNA-Binding ProteinsDNA Mutational AnalysisEndometriosisFemaleGATA3 Transcription FactorHistone-Lysine N-MethyltransferaseHumansImmunohistochemistryMastectomyMiddle AgedMutationNeoplasm ProteinsBiomarkers, TumorDNA-Binding ProteinsGATA3 protein, humanGATA3 Transcription FactorHistone-Lysine N-MethyltransferaseKMT2D protein, humanNeoplasm ProteinsReceptors, EstrogenSETD2 protein, humanBreastEndometriosisPhyllodes tumour

Identifiers

PMID33782741

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.