ArticleNeuroradiology2021
Disrupted brain gray matter networks in drug-naïve participants with essential tremor.
Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Negative emotion modulates postural tremor variability in Parkinson's disease: A multimodal EEG and motion sensor study toward behavioral interventions.IBRO neuroscience reports · 2025Article
- Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor.Journal of molecular neuroscience : MN · 2025Article
- Cognitive impairment after intravenous thrombolysis in mild stroke: assessment of cerebral blood flow covariance network.Frontiers in neurology · 2025Article
- Assessing the Role of Locus Coeruleus Degeneration in Essential Tremor and Parkinson's Disease with Sleep Disorders.Journal of Parkinson's disease · 2024Article
- Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Using histogram analysis of the intrinsic brain activity mapping to identify essential tremor.Frontiers in neurology · 2023Article
- Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy.Network neuroscience (Cambridge, Mass.) · 2022Article
- Disrupted Brain Functional Network Topology in Essential Tremor Patients With Poor Sleep Quality.Frontiers in neuroscience · 2022Article
- Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.Frontiers in aging neuroscience · 2022Article
- Combined brain network topological metrics with machine learning algorithms to identify essential tremor.Frontiers in neuroscience · 2022Article
- Topologically Disrupted Gray Matter Networks in Drug-Naïve Essential Tremor Patients With Poor Sleep Quality.Frontiers in neurology · 2022Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeTo use structural magnetic resonance imaging and graph theory approaches to investigate the topological organization of the brain morphological network based on gray matter in essential tremor, and its potential relation to disease severity.
methodsIn this prospective study conducted from November 2018 to November 2019, 36 participants with essential tremor and 37 matched healthy controls underwent magnetic resonance imaging. Brain networks based on the morphological similarity of gray matter across regions were analyzed using graph theory. Nonparametric permutation testing was used to assess group differences in topological metrics. Support vector machine was applied to the gray matter morphological matrices to classify participants with essential tremor vs. healthy controls.
resultsCompared with healthy controls, participants with essential tremor showed increased global efficiency (p < 0.01) and decreased path length (p < 0.01); abnormal nodal properties in frontal, parietal, and cerebellar lobes; and disconnectivity in cerebello-thalamo-cortical network. The abnormal brain nodal centralities (left superior cerebellum gyrus; right caudate nucleus) correlated with clinical measures, both motor (Fahn-Tolosa-Marìn tremor rating, p = 0.017, r = - 0.41) and nonmotor (Hamilton depression scale, p = 0.040, r = - 0.36; Hamilton anxiety scale, p = 0.008, r = - 0.436). Gray matter morphological matrices classified individuals with high accuracy of 80.0%.
conclusionParticipants with essential tremor showed randomization in global properties and dysconnectivity in the cerebello-thalamo-cortical network. Participants with essential tremor could be distinguished from healthy controls by gray matter morphological matrices.
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