Evidence map›Paper›PMID 33782589›Full record

ArticleNature nanotechnology2021

Bioelectronic control of a microbial community using surface-assembled electrogenetic cells to route signals.

Jessica L Terrell, Tanya Tschirhart, Justin P Jahnke, Kristina Stephens, Yi Liu, Hong Dong, Margaret M Hurley, Maria Pozo, Ryan McKay, Chen Yu Tsao and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Article
  3. Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
  5. Article
  6. Electrochemistry as a Tool for Redox-Based Bio-Information Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Skin-Integrated Electrogenetic Regulation of Vasculature for Accelerated Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Review
  15. Article
  16. Synthetic microbiology in sustainability applications.Nature reviews. Microbiology · 2024
    Review
  17. Article
  18. Biomimetic Wearable Sensors: Emerging Combination of Intelligence and Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jessica L Terrell *U.S. Army Combat Capabilities Development Command (DEVCOM)-Army Research Laboratory, Adelphi, MD, USA.ORCID http://orcid.org/0000-0002-7095-4198
Tanya Tschirhart *Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.ORCID http://orcid.org/0000-0003-2781-981X
Justin P JahnkeU.S. Army Combat Capabilities Development Command (DEVCOM)-Army Research Laboratory, Adelphi, MD, USA.
Kristina StephensFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Yi LiuFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Hong DongU.S. Army Combat Capabilities Development Command (DEVCOM)-Army Research Laboratory, Adelphi, MD, USA.ORCID http://orcid.org/0000-0002-0538-2525
Margaret M HurleyU.S. Army Combat Capabilities Development Command (DEVCOM)-Army Research Laboratory, Aberdeen, MD, USA.
Maria PozoFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Ryan McKayFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Chen Yu TsaoFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Hsuan-Chen WuFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Gary VoraCenter for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.ORCID http://orcid.org/0000-0002-0657-8597
Gregory F PayneFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Dimitra N Stratis-CullumU.S. Army Combat Capabilities Development Command (DEVCOM)-Army Research Laboratory, Adelphi, MD, USA.
William E BentleyFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. bentley@umd.edu.ORCID http://orcid.org/0000-0002-4855-7866

Funding

Accessing molecular communication via synthetic biology and microelectronics – gut on a chip modelR21EB024102 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI BENTLEY, WILLIAM E. · 2017 to 2018
$412k
NIBIB NIH HHS R21 EB024102
6 · The paper itself

Abstract

We developed a bioelectronic communication system that is enabled by a redox signal transduction modality to exchange information between a living cell-embedded bioelectronics interface and an engineered microbial network. A naturally communicating three-member microbial network is 'plugged into' an external electronic system that interrogates and controls biological function in real time. First, electrode-generated redox molecules are programmed to activate gene expression in an engineered population of electrode-attached bacterial cells, effectively creating a living transducer electrode. These cells interpret and translate electronic signals and then transmit this information biologically by producing quorum sensing molecules that are, in turn, interpreted by a planktonic coculture. The propagated molecular communication drives expression and secretion of a therapeutic peptide from one strain and simultaneously enables direct electronic feedback from the second strain, thus enabling real-time electronic verification of biological signal propagation. Overall, we show how this multifunctional bioelectronic platform, termed a BioLAN, reliably facilitates on-demand bioelectronic communication and concurrently performs programmed tasks.

Indexed as

4-Butyrolactonebeta-GalactosidaseCells, ImmobilizedElectrodesElectronicsEquipment DesignEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGoldGranulocyte-Macrophage Colony-Stimulating FactorGreen Fluorescent ProteinsGTP-Binding ProteinsHydrogen PeroxideMicrobiotaMicroorganisms, Genetically-Modified4-Butyrolactonebeta-GalactosidaseEscherichia coli ProteinsGBP3 protein, humanGoldGranulocyte-Macrophage Colony-Stimulating FactorGreen Fluorescent ProteinsGTP-Binding Proteinshomoserine lactoneHydrogen PeroxideoxyR protein, E coliRepressor Proteins

Identifiers

PMID33782589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.