Evidence map›Paper›PMID 33782528›Full record

ArticleScientific reports2021

Evaluation of malignant effusions using MR-based T1 mapping.

D Kuetting, J Luetkens, A Faron, A Isaak, U Attenberger, C C Pieper, L Meffert, C Jansen, A Sprinkart, F Kütting

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Normal values for native TEuropean heart journal. Imaging methods and practice · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

D KuettingDepartment of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany. daniel.kuetting@ukbonn.de.
J LuetkensDepartment of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany.
A FaronDepartment of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany.
A IsaakDepartment of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany.
U AttenbergerDepartment of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany.
C C PieperDepartment of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany.
L MeffertDepartment of Internal Medicine III; Center of Integrated Oncology (CIO) Cologne-Bonn, University of Bonn, Bonn, Germany.
C JansenDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
A Sprinkart *Department of Diagnostic and Interventional Radiology, University of Bonn, Venusberg Campus 1, 53105, Bonn, Germany.
F Kütting *Clinic for Gastroenterology and Hepatology, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r = - 0.97, TMIX: r = - 0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 ± 137 ms) than in malignancy-negative histology fluids (2423 ± 357 ms) as well as than in non-malignant-negative histology fluids (2651 ± 139 ms); post hoc test for all intergroup comparisons: < 0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77-0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.

Identifiers

PMID33782528
PMCPMC8007641

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