Evidence map›Paper›PMID 33782511›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021

Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders.

Jay C Fournier, Michele Bertocci, Cecile D Ladouceur, Lisa Bonar, Kelly Monk, Halimah Abdul-Waalee, Amelia Versace, João Paulo Lima Santos, Satish Iyengar, Boris Birmaher and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
  5. Amygdala-insula response to neutral stimuli and the prospective prediction of anxiety sensitivity.Progress in neuro-psychopharmacology & biological psychiatry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jay C Fournier *University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. fournierjc@upmc.edu.ORCID http://orcid.org/0000-0001-8967-1668
Michele Bertocci *University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3857-1226
Cecile D LadouceurUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4816-0997
Lisa BonarUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kelly MonkUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Halimah Abdul-WaaleeUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Amelia VersaceUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9925-5203
João Paulo Lima SantosUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-0676-8515
Satish IyengarUniversity of Pittsburgh, Pittsburgh, PA, USA.
Boris BirmaherUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mary L PhillipsUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4958-1291
University of Pittsburgh · US

Funding

Children of Bipolar Parents: A High Risk Follow Up Study (also known as Bipolar Offspring Study - BIOS)R01MH060952 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2001 to 2020
$20.4M
NIMH NIH HHS R01 MH060952
6 · The paper itself

Abstract

Affective disorders (AD, including bipolar disorder, BD, and major depressive disorder) are severe recurrent illnesses. Identifying neural markers of processes underlying AD development in at-risk youth can provide objective, "early-warning" signs that may predate onset or worsening of symptoms. Using data (n = 34) from the Bipolar Offspring Study, we examined relationships between neural response in regions supporting executive function, and those supporting self-monitoring, during an emotional n-back task (focusing on the 2-back face distractor versus the 0-back no-face control conditions) and future depressive and hypo/manic symptoms across two groups of youth at familial risk for AD: Offspring of parents with BD (n = 15, age = 14.15) and offspring of parents with non-BD psychopathology (n = 19, age = 13.62). Participants were scanned and assessed twice, approximately 4 years apart. Across groups, less deactivation in the mid-cingulate cortex during emotional regulation (Rate Ratio = 3.07(95% CI:1.09-8.66), χ

Indexed as

Emotional RegulationMajor Depressive DisorderAdolescentDepressionHumansMagnetic Resonance ImagingMood Disorders

Identifiers

PMID33782511
PMCPMC8134479
OpenAlexW3144775413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.