Evidence map›Paper›PMID 33782403›Full record

ArticleNature communications2021

HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.

Ganqian Zhu, Huacheng Luo, Yang Feng, Olga A Guryanova, Jianfeng Xu, Shi Chen, Qian Lai, Arati Sharma, Bing Xu, Zhigang Zhao and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 95 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 2 countries.

Ganqian Zhu *Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Huacheng Luo *Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Yang FengDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Olga A GuryanovaDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.ORCID 0000-0002-6514-8466
Jianfeng XuDepartment of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Shi ChenDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Qian LaiDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.ORCID 0000-0002-4282-7757
Arati SharmaDivision of Hematology/Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Bing XuDepartment of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, 361026, Fujian, China.
Zhigang ZhaoDepartment of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Ru FengDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Hongyu NiDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
David ClaxtonDivision of Hematology/Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Ying GuoDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Ruben A MesaDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Yi QiuPenn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.ORCID 0000-0002-3282-6072
Feng-Chun YangDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Wei LiDivision of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, 92697, USA.ORCID 0000-0001-9931-5990
Stephen D NimerSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Suming HuangDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. shuang4@pennstatehealth.psu.edu.ORCID 0000-0002-4788-2085
Mingjiang XuDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. xum1@uthscsa.edu.ORCID 0000-0002-7063-6253
Pennsylvania State University · USUniversity of Miami · USUniversity of Florida · USBaylor College of Medicine · USFirst Affiliated Hospital of Xiamen University · CNNanfang Hospital · CNThe University of Texas Health Science Center at San Antonio · USTianjin Medical University Cancer Institute and Hospital · CNUniversity of California, Irvine · USWayne State University · US

Funding

Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01CA172408 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2024
$3.4M
Roles of TET2-dependent DNA demethylation intermediates in hematological malignanciesR01HL145883 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2019 to 2022
$2.2M
Role of lincRNAs in HSC function and leukemogenesisR01HL141950 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HUANG, SUMING, XU, MINGJIANG · 2019 to 2022
$2.2M
The role of DNMT3A mutations in clonal heterogeneity and evolution of hematopoiesisR01DK121831 · NIDDK · UNIVERSITY OF FLORIDA · PI GURYANOVA, OLGA A · 2019 to 2023
$1.7M
Epigenetic regulation of hematopoiesisR01HL144712 · NHLBI · UNIVERSITY OF FLORIDA · PI QIU, YI · 2019 to 2022
$1.6M
The Role of Long Noncoding RNA in HematopoiesisR01DK110108 · NIDDK · UNIVERSITY OF FLORIDA · PI HUANG, SUMING · 2016 to 2019
$1.3M
Biologic and therapeutic relevance of DNMT3A mutations in acute myeloid leukemiaR00CA178191 · NCI · UNIVERSITY OF FLORIDA · PI GURYANOVA, OLGA A · 2016 to 2018
$759k
NCI NIH HHS R00 CA178191NCI NIH HHS R01 CA172408NHLBI NIH HHS R01 HL141950NHLBI NIH HHS R01 HL144712NHLBI NIH HHS R01 HL145883NIDDK NIH HHS R01 DK110108NIDDK NIH HHS R01 DK121831
6 · The paper itself

Abstract

Nucleophosmin (NPM1) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded nucleolar protein (NPM1c

Indexed as

Gene Expression Regulation, LeukemicAnimalsCarcinogenesisCell Line, TumorCell ProliferationGene Expression ProfilingHeterograftsHistone-Lysine N-MethyltransferaseHistonesHomeodomain ProteinsHumansLeukemia, Myeloid, AcuteMiceMice, TransgenicMultigene FamilyMutationhistone H3 trimethyl Lys4Histone-Lysine N-MethyltransferaseHistonesHomeodomain ProteinsKMT2A protein, humanMEIS1 protein, humanMyeloid Ecotropic Viral Integration Site 1 ProteinMyeloid-Lymphoid Leukemia ProteinNPM1 protein, humanNpm1 protein, mouseNuclear ProteinsNucleophosminRNA, Long Noncoding

Identifiers

PMID33782403
PMCPMC8007823
OpenAlexW3179915403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.