ArticleNature communications2021
GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
92 citing papers in PubMed, 224 citations in OpenAlex.
- Foliar GR24 and γ-aminobutyric acid modulate redox signaling, root-system architecture, and mineral homeostasis in tellurite-stressed wheat (Plant signaling & behavior · 2026Article
- Minimally invasive quantitative tracking of minerals, sugars, amino acids, and hormones in the leaf apoplast of Arabidopsis thaliana and Vicia faba.Journal of experimental botany · 2026Article
- TaGAD2 is a potential downstream effector of Rht5 in controlling wheat plant height.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Transcriptome analysis reveals the enhancing effects of gamma-aminobutyric acid on the tolerance of grapevines to cadmium stress by reducing cadmium accumulation.Plant biology (Stuttgart, Germany) · 2026Article
- Single-nucleus RNA sequencing reveals a spatiotemporal pattern of HScience China. Life sciences · 2026Article
- Article
- γ-Aminobutyric Acid (GABA) enhances heat tolerance in rice via integrated antioxidant defense, metabolic homeostasis and heat shock response.BMC plant biology · 2026Article
- Advances in the Application of Amino Acids in the Preservation of Postharvest Fruits and Vegetables.Foods (Basel, Switzerland) · 2026Review
- Interpretable multi-omics machine learning reveals drought-driven shifts in plant-microbe interactions.Environmental microbiome · 2026Article
- Decoding the multifunctional role of γ-aminobutyric acid in plant adaptation to drought stress.Planta · 2026Review
- Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings.Plant, cell & environment · 2026Article
- PpZAT12 from a native Kentucky bluegrass (Poa pratensis L.) confers drought tolerance through regulating antioxidant defense system and multiple metabolic pathways.BMC plant biology · 2026Article
- ALMT12: A dual regulator of S-type anion transport in guard cells?Plant physiology · 2026Article
- Interaction of 4-Aminobutyrate (GABA) with the Tricarboxylic Acid Cycle in Plants Under Salinity Stress.Plants (Basel, Switzerland) · 2026Review
- Effects of exogenous γ-aminobutyric acid concentrations on growth and nutrient uptake in trifoliate orange (Frontiers in plant science · 2026Article
- Interaction Between CsATG8f and CsRAP2.12 Modulates Antioxidant Defense and Hypoxia Response During Submergence inInternational journal of molecular sciences · 2025Article
- Investigating the alleviatory ability of bio-synthesized zinc oxide nanoparticles from Sargassum ilicifolium (Turner) C. Agardh on the tomato plants exposed to whitefly infestation.Scientific reports · 2025Article
- Vegetation carbon use efficiency response to drought in the Manas River Basin of Xinjiang.Scientific reports · 2025Article
- Integrated lipidomics and physiological analyses reveal the critical role of leaf sheath wax remodeling in wheat (Triticum aestivum L.) drought resistance.BMC plant biology · 2025Article
- Advanced phenotyping features utilizing deep learning techniques for automated analysis of stomatal guard cell orientation.Scientific reports · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The non-protein amino acid γ-aminobutyric acid (GABA) has been proposed to be an ancient messenger for cellular communication conserved across biological kingdoms. GABA has well-defined signalling roles in animals; however, whilst GABA accumulates in plants under stress it has not been determined if, how, where and when GABA acts as an endogenous plant signalling molecule. Here, we establish endogenous GABA as a bona fide plant signal, acting via a mechanism not found in animals. Using Arabidopsis thaliana, we show guard cell GABA production is necessary and sufficient to reduce stomatal opening and transpirational water loss, which improves water use efficiency and drought tolerance, via negative regulation of a stomatal guard cell tonoplast-localised anion transporter. We find GABA modulation of stomata occurs in multiple plants, including dicot and monocot crops. This study highlights a role for GABA metabolism in fine tuning physiology and opens alternative avenues for improving plant stress resilience.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.