Evidence map›Paper›PMID 33782147›Full record

ArticleSexually transmitted infections2022

Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019.

Heli Harvala, Claire Reynolds, Samreen Ijaz, Vicki Maddox, Sujan Dilly Penchala, Alieu Amara, Laura Else, Susan Brailsford, Saye Khoo

Open access · hybridAbstract read
In one paragraph

Article in Sexually transmitted infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Suppressed HIV antibody responses following exposure to antiretrovirals-evidence from PrEP randomized trials and early antiretroviral treatment initiation studies.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  6. Article
  7. Article
  8. Undeclared pre-exposure or post-exposure prophylaxis (PrEP/PEP) use among syphilis-positive blood donors, England, 2020 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Heli HarvalaMicrobiology Services, NHS Blood and Transplant, London, UK heli.harvalasimmonds@nhsbt.nhs.uk.ORCID 0000-0001-9154-4190
Claire ReynoldsNHS Blood and Transplant/Public Health England Epidemiology Unit, NHS Blood and Transplant, London, UK.
Samreen IjazNational Infection Service, Public Health England, London, UK.
Vicki MaddoxMicrobiology Services, NHS Blood and Transplant, London, UK.
Sujan Dilly PenchalaDepartment of Pharmacology, University of Liverpool, Liverpool, UK.
Alieu AmaraDepartment of Pharmacology, University of Liverpool, Liverpool, UK.
Laura ElseDepartment of Pharmacology, University of Liverpool, Liverpool, UK.
Susan BrailsfordMicrobiology Services, NHS Blood and Transplant, London, UK.
Saye KhooDepartment of Pharmacology, University of Liverpool, Liverpool, UK.
NHS Blood and Transplant · GBUniversity of Liverpool · GBPublic Health England · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDue to increased use of pre-exposure prohylaxis (PrEP) and its potential to affect HIV screening of blood donors, we undertook antiretroviral residual testing among HIV-negative male donors in England.

methodsResidual plasma samples were obtainnd from 46 male donors confirmed positive for syphilis and 96 donors who were repeat reactive for HIV antibodies in screening but confirmed as HIV-negative by reference testing. These were tested for concentrations of tenofovir and emtricitabine by high-performance liquid chromatograhpy coupled with mass spectrometry.

resultsWe found evidence of pre-exposure or post-exposure prophylaxis (PrEP/PEP) use in three male blood donors confirmed positive for syphilis (3 out of 46 screened, 6.5%). Two were estimated to have taken PrEP/PEP within a day of donating, and the third within 2 days. Two were new donors, whereas one had donated previously but acquired syphilis infection after his last donation.

conclusionsOur findings indicate that a small proportion of blood donors have not been disclosing PrEP/PEP use and therefore donating in non-compliance to donor eligibility criteria.

Indexed as

Blood DonorsAdultAgedAnti-HIV AgentsEnglandHIV InfectionsHomosexuality, MaleHumansMaleMass ScreeningMiddle AgedPilot ProjectsPost-Exposure ProphylaxisPre-Exposure ProphylaxisAnti-HIV Agentsdisease transmissionHIVinfectiouspre-exposure prophylaxissyphilis

Identifiers

PMID33782147
PMCPMC8862030
OpenAlexW3150158479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.