Evidence map›Paper›PMID 33782138›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions.

Akil Hamza, Leanne Amitzi, Lina Ma, Maureen R M Driessen, Nigel J O'Neil, Philip Hieter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. DNA Replication Errors Drive Genome-Wide Small Inverted Triplication Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Deep structure-function analysis of the endonuclease Mus81 with dominant mutational scanning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Setting molecular traps in yeast for identification of anticancer drug targets.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Akil HamzaMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-3613-8744
Leanne AmitziMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-4914-8327
Lina MaMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0001-7768-5990
Maureen R M DriessenMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Nigel J O'NeilMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-1992-6976
Philip HieterMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada hieter@msl.ubc.ca.
University of British Columbia · CA

Funding

CIHR FDN 148449CIHR MOP 38096
6 · The paper itself

Abstract

Genetic screens can identify synthetic lethal (SL) interactions and uncover potential anticancer therapeutic targets. However, most SL screens have utilized knockout or knockdown approaches that do not accurately mimic chemical inhibition of a target protein. Here, we test whether missense mutations can be utilized as a model for a type of protein inhibition that creates a dominant gain-of-function cytotoxicity. We expressed missense mutations in the

Indexed as

Mutation, MissenseSynthetic Lethal MutationsAntineoplastic AgentsChromosomal Proteins, Non-HistoneDNADrug DevelopmentFlap EndonucleasesGenetic TechniquesHumansProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAntineoplastic AgentsCHL1 protein, S cerevisiaeChromosomal Proteins, Non-HistoneDNAFEN1 protein, humanFlap EndonucleasesSaccharomyces cerevisiae ProteinsChl1 helicaseDNA trappingdominant missense mutationsdominant synthetic lethalityFen1 endonuclease

Identifiers

PMID33782138
PMCPMC8040598
OpenAlexW3141859196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.