ArticleProceedings of the National Academy of Sciences of the United States of America2021
A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- The NKCC1 Inhibitor Bumetanide Restores Cortical Feedforward Inhibition and Lessens Sensory Hypersensitivity in Early Postnatal Fragile X Mice.Biological psychiatry · 2025Article
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Heterogeneous subpopulations of GABAiScience · 2024Article
- Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus.Frontiers in cellular neuroscience · 2024Article
- Somatosensory-Evoked Early Sharp Waves in the Neonatal Rat Hippocampus.International journal of molecular sciences · 2023Article
- Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo.eLife · 2022Article
- Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development.BMC medicine · 2022Article
- The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion.eLife · 2022Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity.Frontiers in molecular neuroscience · 2021Article
- When Are Depolarizing GABAergic Responses Excitatory?Frontiers in molecular neuroscience · 2021Review
- Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance.Frontiers in cellular neuroscience · 2021Review
- Neurophysiology of the Developing Cerebral Cortex: What We Have Learned and What We Need to Know.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NKCC1 is the primary transporter mediating chloride uptake in immature principal neurons, but its role in the development of in vivo network dynamics and cognitive abilities remains unknown. Here, we address the function of NKCC1 in developing mice using electrophysiological, optical, and behavioral approaches. We report that NKCC1 deletion from telencephalic glutamatergic neurons decreases in vitro excitatory actions of γ-aminobutyric acid (GABA) and impairs neuronal synchrony in neonatal hippocampal brain slices. In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visual cortex. Moreover, long-term effects of the developmental NKCC1 deletion on synaptic maturation, network dynamics, and behavioral performance are subtle. Our data reveal a neural network function of NKCC1 in hippocampal glutamatergic neurons in vivo, but challenge the hypothesis that NKCC1 is essential for major aspects of hippocampal development.
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