Evidence map›Paper›PMID 33782117›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Upgraded CRISPR/Cas9 tools for tissue-specific mutagenesis in

Gabriel T Koreman, Yineng Xu, Qinan Hu, Zijing Zhang, Sarah E Allen, Mariana F Wolfner, Bei Wang, Chun Han

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Tuning mitotic recombination with patterned DNA nicks for precision mosaic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  12. Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Tissue-specific knockout inbioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gabriel T KoremanDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Yineng XuDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-4473-4052
Qinan HuDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-3653-3004
Zijing ZhangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Sarah E AllenDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-1646-629X
Mariana F WolfnerDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2701-9505
Bei WangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853; bw447@cornell.edu chun.han@cornell.edu.ORCID 0000-0003-3002-3302
Chun HanDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853; bw447@cornell.edu chun.han@cornell.edu.ORCID 0000-0001-7319-8095
Cornell University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
New Targets for Reproductive Control of Mosquito VectorsR01AI095491 · NIAID · CORNELL UNIVERSITY · PI Laura C Harrington, Mariana Federica Wolfner · 2011 to 2026
$7.3M
Mechanisms of the recognition of degenerating dendritesR01NS099125 · NINDS · CORNELL UNIVERSITY · PI HAN, CHUN · 2016 to 2020
$2.1M
Drosophila as a model to dissect the rise and role of calcium in egg activation.R21HD088744 · NICHD · CORNELL UNIVERSITY · PI WOLFNER, MARIANA FEDERICA · 2016 to 2017
$424k
A light-inducible protein trapping system for studying cellular dynamics in DrosophilaR21OD023824 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2017 to 2018
$414k
NIAID NIH HHS R01 AI095491NICHD NIH HHS R21 HD088744NIH HHS P40 OD018537NIH HHS R21 OD023824NINDS NIH HHS R01 NS099125
6 · The paper itself

Abstract

CRISPR/Cas9 has emerged as a powerful technology for tissue-specific mutagenesis. However, tissue-specific CRISPR/Cas9 tools currently available in

Indexed as

CRISPR-Cas SystemsGenetic TechniquesMutagenesisAnimalsDrosophilaFemaleMaleRNA, Guide, CRISPR-Cas SystemsRNA, Guide, CRISPR-Cas Systemsco-CRISPRCRISPR/Cas9CRISPR-TRiMDrosophilagRNA

Identifiers

PMID33782117
PMCPMC8040800
OpenAlexW3147721083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.