Evidence map›Paper›PMID 33782089›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease.

Philip S Crooke, John T Tossberg, Krislyn P Porter, Thomas M Aune

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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  13. Recent advances in neutrophil chemotaxis abnormalities during sepsis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Philip S CrookeDepartment of Mathematics, Vanderbilt University, Nashville, TN 37212.ORCID 0000-0003-3872-3290
John T TossbergDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; and.
Krislyn P PorterDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; and.ORCID 0000-0002-3680-3636
Thomas M AuneDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; and tom.aune@vumc.org.ORCID 0000-0002-4968-4306
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

IFN GAMMA GENE REGULATION IN T CELLS AND NK CELLSR01AI044924 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUNE, THOMAS M. · 2000 to 2019
$5.8M
Alu RNAs and double-stranded RNA sensorsR21AI144193 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUNE, THOMAS M. · 2019 to 2020
$468k
NIAID NIH HHS R01 AI044924NIAID NIH HHS R21 AI144193
6 · The paper itself

Abstract

Severe COVID-19 disease is associated with elevated inflammatory responses. One form of Aicardi-Goutières syndrome caused by inactivating mutations in

Indexed as

SARS-CoV-2Severity of Illness IndexAdenosineAlu ElementsCOVID-19Dendritic CellsGenome, HumanHumansInosineInterferon Regulatory FactorsNF-kappa BRNA, Double-StrandedRNA EditingRNA-SeqSignal TransductionAdenosineInosineInterferon Regulatory FactorsNF-kappa BRNA, Double-Stranded

Identifiers

PMID33782089
PMCPMC8183577
OpenAlexW3144279346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.