ArticleLife science alliance2021
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages.
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Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
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Who cites it
82 citing papers in PubMed, 136 citations in OpenAlex.
- miR-155-5p drives coordinated tumor and macrophage reprogramming across multiple cancer entities.BMC medicine · 2026Article
- Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer.Cancer immunology research · 2026Article
- Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation.World journal of biological chemistry · 2026Review
- Post-Surgical Remodeling of Circulating Monocytes Identifies CD86 Expression on Non-Classical Monocytes as a Prognostic Indicator in Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2026Article
- DADA-EV: domain-adaptive diffusion autoencoder for estimating tissue- and cell-type-specific origin in extracellular vesicle transcriptomes.Briefings in bioinformatics · 2026Article
- The mechanisms and clinical prospects of combining chemotherapy with immunotherapy for advanced pancreatic cancer.Discover oncology · 2026Review
- Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation.Cancer research · 2026Article
- Trem2 activation by renal tubular debris sustains Arg1Frontiers in immunology · 2026Article
- TREM2-expressing macrophages in liver diseases.Trends in endocrinology and metabolism: TEM · 2026Review
- An Investigation to Study Morphology, Nanomechanical Attributes, Transcriptomics, and Proteomics of Tumor Associated Macrophages Derived Extracellular Vesicles in the Tumor Microenvironment.Journal of analytical oncology · 2026Article
- Don't judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good.npj biomedical innovations · 2026Review
- The tumour microenvironment in pancreatic cancer - new clinical challenges, but more opportunities.Nature reviews. Clinical oncology · 2025Review
- Nicheformer: a foundation model for single-cell and spatial omics.Nature methods · 2025Article
- TREM2-mediated regulation of myeloid cells in the tumor microenvironment: new insights and therapeutic prospects.NPJ precision oncology · 2025Review
- Nonredundant Immune Checkpoints Direct Therapeutic Resistance to Chemoimmunotherapy in Pancreatic Ductal Adenocarcinoma.Cancer immunology research · 2025Article
- Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition.Journal of translational medicine · 2025Article
- Pancreatic Cancer Detection and Differentiation from Chronic Pancreatitis: Potential Biomarkers Identified through a High-Throughput Multiplex Proteomic Assay and Machine Learning-Based Analysis.Annals of laboratory medicine · 2025Article
- TREM2 Depletion in Pancreatic Cancer Elicits Pathogenic Inflammation and Accelerates Tumor Progression via Enriching IL-1βGastroenterology · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 1 institution in 1 country.
Samantha B KempDepartments of Molecular and Cellular Pathology, University of Michigan, Ann Arbor, MI, USA.
Nina G SteeleCell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Eileen S CarpenterInternal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Katelyn L DonahueCancer Biology, University of Michigan, Ann Arbor, MI, USA.
Grace G BushnellBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Aaron H MorrisBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Stephanie TheComputational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Sophia M OrbachBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Veerin R SirihorachaiCancer Biology, University of Michigan, Ann Arbor, MI, USA.
Zeribe C NwosuMolecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Carlos EspinozaSurgery, University of Michigan, Ann Arbor, MI, USA.
Fatima LimaSurgery, University of Michigan, Ann Arbor, MI, USA.
Kristee BrownSurgery, University of Michigan, Ann Arbor, MI, USA.
Alexander A GirgisSurgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-4706-5480
Valerie GunchickInternal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.
Yaqing ZhangSurgery, University of Michigan, Ann Arbor, MI, USA.
Costas A LyssiotisMolecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9309-6141
Timothy L FrankelSurgery, University of Michigan, Ann Arbor, MI, USA.
Filip BednarSurgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5193-9817
Arvind RaoBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Vaibhav SahaiInternal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1892-1548
Lonnie D SheaBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Howard C CrawfordCancer Biology, University of Michigan, Ann Arbor, MI, USA hcrawfo1@hfhs.org.ORCID 0000-0001-9360-3019
Marina Pasca di MaglianoCell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA marinapa@umich.edu.ORCID 0000-0001-9632-9035
University of Michigan · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5MTissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3MTraining Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3MSynthesizing Image-derived Heterogeneity with Genomic measurements for Assessing Disease Aggressiveness in Lower Grade GliomasR37CA214955 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KURTEK, SEBASTIAN, RAO, ARVIND · 2018 to 2024
$3.9MTraining in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6MMechanisms of Pancreatic Inflammation, Tissue Repair and CarcinogenesisR01CA151588 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA · 2010 to 2020
$3.3MInterrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas CancerU01CA224145 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRAWFORD, HOWARD C., PASCA DI MAGLIANO, MARINA · 2017 to 2021
$2.6MIntratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6MMetaplastic Tuft Cells in Pancreatic CancerR01CA247516 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRAWFORD, HOWARD C. · 2020 to 2024
$2.3MDosage-Dependent Hedgehog Signaling in Pancreatic CancerR01CA198074 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN, PASCA DI MAGLIANO, MARINA · 2015 to 2019
$1.9MTraining Program in Translational ResearchT32GM113900 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P, NIKOLOVSKA-COLESKA, ZANETA · 2016 to 2020
$991kNCI NIH HHS F31 CA247076NCI NIH HHS F32 CA243421NCI NIH HHS K08 CA201581NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA151588NCI NIH HHS R01 CA198074NCI NIH HHS R01 CA247516NCI NIH HHS R37 CA214955NCI NIH HHS R37 CA237421NCI NIH HHS R50 CA232985NCI NIH HHS T32 CA009676NCI NIH HHS U01 CA224145NIBIB NIH HHS K99 EB028840NIBIB NIH HHS R00 EB028840NIDCR NIH HHS T32 DE007057NIDDK NIH HHS P30 DK034933NIDDK NIH HHS T32 DK094775NIGMS NIH HHS T32 GM113900
Abstract
Pancreatic ductal adenocarcinoma (PDA) is accompanied by reprogramming of the local microenvironment, but changes at distal sites are poorly understood. We implanted biomaterial scaffolds, which act as an artificial premetastatic niche, into immunocompetent tumor-bearing and control mice, and identified a unique tumor-specific gene expression signature that includes high expression of
Indexed as
AdultAnimalsCarcinoma, Pancreatic DuctalCarrier ProteinsComplement C1qFemaleGene ExpressionGene Expression Regulation, NeoplasticHumansMacrophagesMaleMembrane GlycoproteinsMiceMice, Inbred C57BLMitochondrial ProteinsMonocytesC1QA protein, humanC1qa protein, mouseC1QBP protein, humanCarrier Proteinscomplement 1q receptorComplement C1qMembrane GlycoproteinsMitochondrial ProteinsReceptors, ComplementReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.