ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Unraveling the Temporal Dynamics of Reward Signals in Music-Induced Pleasure with TMS.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06174740 (Neural Correlates of Multisensory Stimulation in Healthy Older Adults), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neural Correlates of Multisensory Stimulation in Healthy Older Adults
Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises.Molecular psychiatry · 2025Trial
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Continuous Theta Burst to Supplementary Motor Area Modulates Groove.Annals of the New York Academy of Sciences · 2026Article
- Functional Connectivity of Auditory, Motor, and Reward Networks at Rest and During Music Listening.Brain sciences · 2025Article
- Article
- Sensory Entrained TMS (seTMS) Enhances Motor Cortex Excitability.Human brain mapping · 2025Article
- Understanding Music Participation for Adults With Down Syndrome.Journal of intellectual disability research : JIDR · 2025Article
- The Eastern Association of Electroencephalographers: A Canadian/USA success story.Clinical neurophysiology practice · 2025Review
- Effects of Raga music and Chinese five-element on milk production, antioxidant, neuroendocrine, immune, and welfare indicators in dairy cows.Frontiers in veterinary science · 2025Article
- Assessing the Acceptability and Potential Emotional Well-being Outcomes of a Digital, Intergenerational Music Program for Older Adults Living With Dementia.Journal of intergenerational relationships · 2025Article
- Article
- Music therapy with adults in the subacute phase after stroke: A study protocol.Contemporary clinical trials communications · 2024Article
- State-dependent connectivity in auditory-reward networks predicts peak pleasure experiences to music.PLoS biology · 2024Article
- Generating New Musical Preferences From Multilevel Mapping of Predictions to Reward.Psychological science · 2024Article
- Revisiting the musical reminiscence bump: insights from neurocognitive and social brain development in adolescence.Frontiers in psychology · 2024Article
- Lyrics do matter: how "coping songs" relate to well-being goals. The COVID pandemic case.Frontiers in psychology · 2024Article
- Auditory and reward structures reflect the pleasure of musical expectancies during naturalistic listening.Frontiers in neuroscience · 2023Article
- Inter-subject correlations of EEG reflect subjective arousal and acoustic features of music.Frontiers in human neuroscience · 2023Article
- Music and Brain Circuitry: Strategies for Strengthening Evidence-Based Research for Music-Based Interventions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Exploring the Effects of Brain Stimulation on Musical Taste: tDCS on the Left Dorso-Lateral Prefrontal Cortex-A Null Result.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Music's ability to induce feelings of pleasure has been the subject of intense neuroscientific research lately. Prior neuroimaging studies have shown that music-induced pleasure engages cortico-striatal circuits related to the anticipation and receipt of biologically relevant rewards/incentives, but these reports are necessarily correlational. Here, we studied both the causal role of this circuitry and its temporal dynamics by applying transcranial magnetic stimulation (TMS) over the left dorsolateral PFC combined with fMRI in 17 male and female participants. Behaviorally, we found that, in accord with previous findings, excitation of fronto-striatal pathways enhanced subjective reports of music-induced pleasure and motivation, whereas inhibition of the same circuitry led to the reduction of both. fMRI activity patterns indicated that these behavioral changes were driven by bidirectional TMS-induced alteration of fronto-striatal function. Specifically, changes in activity in the NAcc predicted modulation of both hedonic and motivational responses, with a dissociation between pre-experiential versus experiential components of musical reward. In addition, TMS-induced changes in the fMRI functional connectivity between the NAcc and frontal and auditory cortices predicted the degree of modulation of hedonic responses. These results indicate that the engagement of cortico-striatal pathways and the NAcc, in particular, is indispensable to experience rewarding feelings from music.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.