Evidence map›Paper›PMID 33782005›Full record

ArticleAntimicrobial agents and chemotherapy2021

Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019.

Beatriz Mengual-Chuliá, Andrés Alonso-Cordero, Laura Cano, M Del Mar Mosquera, Patricia de Molina, Roser Vendrell, Mariana Reyes-Prieto, Mireia Jané, Nuria Torner, Ana Isabel Martínez and 4 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Beatriz Mengual-ChuliáVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain.
Andrés Alonso-CorderoVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain.
Laura CanoVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain.
M Del Mar MosqueraMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain.
Patricia de MolinaMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain.
Roser VendrellMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain.
Mariana Reyes-PrietoBioinformatics and Sequencing Service, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain.
Mireia JanéPublic Health Agency of Catalonia, Barcelona, Spain.
Nuria TornerPublic Health Agency of Catalonia, Barcelona, Spain.
Ana Isabel MartínezPublic Health Agency of Catalonia, Barcelona, Spain.
Jordi VilaMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain.ORCID 0000-0002-8025-3926
Javier Díez-DomingoVaccine Research Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain.
M Ángeles Marcos *Microbiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain.
F Xavier López-Labrador *Virology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain F.Xavier.Lopez@uv.es.
Generalitat Valenciana · ESUniversitat de Barcelona · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.

Indexed as

Influenza A virusInfluenza, HumanAntiviral AgentsDrug Resistance, ViralHumansSpainAntiviral Agentsantiviralsbaloxavirfavipiravirnext-generation sequencingpimodivirwhole-genome sequencing

Identifiers

PMID33782005
PMCPMC8315920
OpenAlexW3146029272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.