Evidence map›Paper›PMID 33781918›Full record

ArticleJournal of biomedical informatics2021

Extracting COVID-19 diagnoses and symptoms from clinical text: A new annotated corpus and neural event extraction framework.

Kevin Lybarger, Mari Ostendorf, Matthew Thompson, Meliha Yetisgen

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Using large language models to identify prediagnostic clinical features of ovarian cancer from healthcare records: a population-based case-control study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
  2. Article
  3. CACER: Clinical concept Annotations for Cancer Events and Relations.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  4. Article
  5. Article
  6. Coronavirus Anatomy and Its Analytical Approaches for Targeting COVID-19.Advances in experimental medicine and biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Machine learning approaches for electronic health records phenotyping: a methodical review.Journal of the American Medical Informatics Association : JAMIA · 2023
    Article
  14. Generalizing through Forgetting - Domain Generalization for Symptom Event Extraction in Clinical Notes.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023
    Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kevin LybargerBiomedical & Health Informatics, University of Washington, Box 358047, Seattle, WA 98109, USA. Electronic address: lybarger@uw.edu.
Mari OstendorfDepartment of Electrical & Computer Engineering, University of Washington, Campus Box 352500 185, Seattle, WA 98195-2500, USA.
Matthew ThompsonDepartment of Family Medicine, University of Washington, Box 354696, Seattle, WA 98195-2500, USA.
Meliha YetisgenBiomedical & Health Informatics, University of Washington, Box 358047, Seattle, WA 98109, USA.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
University of Washington Biomedical Informatics and Data Science Research Training ProgramT15LM007442 · NLM · UNIVERSITY OF WASHINGTON · PI JOHN H. GENNARI, Andrea L. Hartzler · 2002 to 2026
$19.6M
Extraction of Symptom Burden from Clinical Narratives of Cancer Patients using Natural Language ProcessingR21CA258242 · NCI · UNIVERSITY OF WASHINGTON · PI YETISGEN, MELIHA · 2021 to 2022
$719k
NCATS NIH HHS UL1 TR002319NCI NIH HHS R21 CA258242NLM NIH HHS T15 LM007442
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic. Although much has been learned about the novel coronavirus since its emergence, there are many open questions related to tracking its spread, describing symptomology, predicting the severity of infection, and forecasting healthcare utilization. Free-text clinical notes contain critical information for resolving these questions. Data-driven, automatic information extraction models are needed to use this text-encoded information in large-scale studies. This work presents a new clinical corpus, referred to as the COVID-19 Annotated Clinical Text (CACT) Corpus, which comprises 1,472 notes with detailed annotations characterizing COVID-19 diagnoses, testing, and clinical presentation. We introduce a span-based event extraction model that jointly extracts all annotated phenomena, achieving high performance in identifying COVID-19 and symptom events with associated assertion values (0.83-0.97 F1 for events and 0.73-0.79 F1 for assertions). Our span-based event extraction model outperforms an extractor built on MetaMapLite for the identification of symptoms with assertion values. In a secondary use application, we predicted COVID-19 test results using structured patient data (e.g. vital signs and laboratory results) and automatically extracted symptom information, to explore the clinical presentation of COVID-19. Automatically extracted symptoms improve COVID-19 prediction performance, beyond structured data alone.

Indexed as

Electronic Health RecordsSymptom AssessmentCOVID-19HumansInformation Storage and RetrievalNatural Language ProcessingCoronavirusCOVID-19Information extractionMachine learningNatural language processing

Identifiers

PMID33781918
PMCPMC7997694

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.