Evidence map›Paper›PMID 33781899›Full record

ArticleOsteoarthritis and cartilage2021

Synovial fluid concentrations of matrix Metalloproteinase-3 and Interluekin-6 following anterior cruciate ligament injury associate with gait biomechanics 6 months following reconstruction.

A Evans-Pickett, L Longobardi, J T Spang, R A Creighton, G Kamath, H C Davis-Wilson, R Loeser, J T Blackburn, B Pietrosimone

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  16. Linking Gait Biomechanics and Daily Steps After ACL Reconstruction.Medicine and science in sports and exercise · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

A Evans-PickettMOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: alyssa7evans@unc.edu.
L LongobardiThurston Arthritis Research Center, University of North Carolina at Chapel Hill, 27599, USA.
J T SpangDepartment of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA.
R A CreightonDepartment of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA.
G KamathDepartment of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA.
H C Davis-WilsonMOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
R LoeserThurston Arthritis Research Center, University of North Carolina at Chapel Hill, 27599, USA.
J T BlackburnMOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA.
B PietrosimoneMOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill · US

Funding

Posttraumatic Osteoarthritis: Establishing a Comprehensive Evaluation StrategyR03AR066840 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIETROSIMONE, BRIAN · 2015 to 2016
$152k
NIAMS NIH HHS R03 AR066840
6 · The paper itself

Abstract

objectiveTo compare gait biomechanics 6 months following anterior cruciate ligament (ACL) reconstruction (ACLR) between patients with the highest and lowest concentrations of synovial fluid (SF) interleukin-6 (IL-6) and matrix metalloproteinase-3 (MMP-3), as well as compared to uninjured controls.

designSF concentrations of IL-6 and MMP-3 were collected 7 ± 4 days post injury in 38 ACL injured patients (55% female, 21±4yrs, 25.3 ± 5.2BMI). ACL injured individuals were stratified into the lowest and highest quartiles based on IL-6 (IL-6

resultsCompared to uninjured controls, IL-6

conclusionsHigh SF concentrations of a proinflammatory cytokine and a degradative enzyme early post-ACL injury are associated with aberrant gait biomechanics in the injured limb at 6 months post-ACLR (i.e., lesser vGRF, KFA and KEM) linked to posttraumatic osteoarthritis development.

Indexed as

Anterior Cruciate Ligament InjuriesBiomechanical PhenomenaCase-Control StudiesFemaleGaitHumansInterleukin-6MaleMatrix Metalloproteinase 3Synovial FluidYoung AdultInterleukin-6Matrix Metalloproteinase 3MMP3 protein, humanACLBiomarkersInflammationKneePosttraumatic osteoarthritis

Identifiers

PMID33781899
PMCPMC8658576
OpenAlexW3144117633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.