ArticleJournal of molecular and cellular cardiology2021
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.
Open access · greenAbstract read
In one paragraph
Article in Journal of molecular and cellular cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Myocarditis in Hypertrophic Cardiomyopathy: Incidence and Contribution to Disease Progression and Outcome.Reviews in cardiovascular medicine · 2025Pooled it
- Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure.Basic research in cardiology · 2026Article
- LncRNA Foxo6os as a Novel " Scaffold" Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- The D75N and P161S Mutations in the C0-C2 Fragment of cMyBP-C Associated with Hypertrophic Cardiomyopathy Disturb the Thin Filament Activation, Nucleotide Exchange in Myosin, and Actin-Myosin Interaction.International journal of molecular sciences · 2024Article
- Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction inJournal of molecular and cellular cardiology plus · 2024Article
- Hypertrophic cardiomyopathy inThe journal of cardiovascular aging · 2024Article
- Bringing into focus the central domains C3-C6 of myosin binding protein C.Frontiers in physiology · 2024Review
- Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- The contribution of N-terminal truncated cMyBPC to in vivo cardiac function.The Journal of general physiology · 2023Article
- Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle.The Journal of general physiology · 2023Article
- Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs.Experimental & molecular medicine · 2023Review
- Myofilament-associated proteins with intrinsic disorder (MAPIDs) and their resolution by computational modeling.Quarterly reviews of biophysics · 2023Review
- Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity.JACC. Basic to translational science · 2022Article
- Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.Journal of the American Heart Association · 2022Article
- GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation.Circulation research · 2022Article
- Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 12 institutions in 3 countries.
Thomas L LynchDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA.
Mohit KumarDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA; Heart, Lung and Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
James W McNamaraHeart, Lung and Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Diederik W D KusterDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Mayandi SivaguruInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Rohit R SinghHeart, Lung and Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Michael J PrevisDepartment of Molecular Physiology and Biophysics, Cardiovascular Research Institute, University of Vermont, Burlington, VT 05405, USA.
Kyoung Hwan LeeDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Gina KuffelDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA.
Michael J ZillioxDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA.
Brian Leei LinDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA.
Weikang MaCenter for Synchrotron Radiation Research and Instrumentation and Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Aaron M GibsonDepartment of Pediatrics, Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Burns C BlaxallDepartment of Pediatrics, Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Michelle L NiemanDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
John N LorenzDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Dana M LeichterResearch Service, Providence VA Medical Center, Providence, RI 02908, USA.
Owen P LearyResearch Service, Providence VA Medical Center, Providence, RI 02908, USA.
Paul M L JanssenDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA.
Pieter P de TombeDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA; Department of Physiology, University of Illinois at Chicago, Chicago 60612, USA; Phymedexp, Université de Montpellier, Inserm, CNRS, Montpellier, France.
Richard J GilbertResearch Service, Providence VA Medical Center, Providence, RI 02908, USA.
Roger CraigDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Thomas IrvingCenter for Synchrotron Radiation Research and Instrumentation and Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
David M WarshawDepartment of Molecular Physiology and Biophysics, Cardiovascular Research Institute, University of Vermont, Burlington, VT 05405, USA.
Sakthivel SadayappanDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA; Heart, Lung and Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address: sadayasl@ucmail.uc.edu.
Loyola University Chicago · USProvidence VA Medical Center · USCincinnati Children's Hospital Medical Center · USIllinois Institute of Technology · USUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · USUniversity of Massachusetts Chan Medical School · USUniversity of Vermont · USThe Ohio State University · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · USVrije Universiteit Amsterdam · NL
Funding
Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2000 to 2020
$42.4MVentricular and Cardiac Fiber Characterization and Integration CoreP01HL059408 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI WARSHAW, DAVID M · 1999 to 2014
$26.4MTime resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9MFrequency-dependent modulation of cardiac myofilament function in health/diseaseR01HL113084 · NHLBI · OHIO STATE UNIVERSITY · PI JANSSEN, PAULUS ML · 2012 to 2023
$4.6MFast myosin binding protein-C and cardiac contractility in heart failureR01HL105826 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2011 to 2025
$4.5MMechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein CR01HL139883 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CRAIG, ROGER W, RALPHE, JOHN CARTER · 2018 to 2021
$2.7MSkeletal Myosin-Binding Protein C (MyBP-C): Molecular Structure and FunctionR01AR067279 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W, WARSHAW, DAVID M · 2015 to 2019
$2.3MCardiac Myosin-Binding Protein C: Molecular Modulation of Actomyosin Function.R01HL126909 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI WARSHAW, DAVID M · 2015 to 2018
$1.9MMurine 3D Engineered Tissue Model of Human MYBPC3 MutationsR01HL107367 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI RALPHE, JOHN CARTER · 2011 to 2015
$1.8MSlow myosin binding protein-C in skeletal muscle physiologyR01AR078001 · NIAMS · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2020 to 2023
$1.8MIGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injuryR01HL143490 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2019 to 2022
$1.6MStimulating Access to Research in the University of Cincinnati Internal Medicine Residency ProgramR38HL155775 · NHLBI · UNIVERSITY OF CINCINNATI · PI Jack Rubinstein · 2021 to 2026
$1.6MNHLBI NIH HHS P01 HL059408NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R00 HL124041NHLBI NIH HHS R01 HL105826NHLBI NIH HHS R01 HL107367NHLBI NIH HHS R01 HL113084NHLBI NIH HHS R01 HL126909NHLBI NIH HHS R01 HL130356NHLBI NIH HHS R01 HL139883NHLBI NIH HHS R01 HL143490NHLBI NIH HHS R38 HL155775NIAMS NIH HHS R01 AR067279NIAMS NIH HHS R01 AR078001NIGMS NIH HHS P41 GM103622
Abstract
Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein's amino terminal (N')-region (C0-C2 domains, 358 amino acids). On the other hand, dephosphorylation of cMyBP-C during myocardial injury results in cleavage of the 271 amino acid C0-C1f region and subsequent contractile dysfunction. Yet, our current understanding of amino terminus region of cMyBP-C in the context of regulating thin and thick filament interactions is limited. A novel cardiac-specific transgenic mouse model expressing cMyBP-C, but lacking its C0-C1f region (cMyBP-C
Indexed as
Protein Interaction Domains and MotifsAnimalsCarrier ProteinsHeartMagnetic Resonance ImagingMiceMice, TransgenicMyocardial ContractionMyocardiumMyocytes, CardiacMyosin Binding Protein CPhosphorylationSarcomeresCarrier ProteinsMyosin Binding Protein CcMyBP-C phosphorylationHeart failureMYBPC3MyofilamentSarcomere
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.