Evidence map›Paper›PMID 33781697›Full record

SynthesisHeart, lung & circulation2021

Atrial Fibrillation as a Predictor of Mortality in High Risk COVID-19 Patients: A Multicentre Study of 171 Patients.

Randy J Ip, Abbas Ali, Zulfiqar Qutrio Baloch, Abdullah Al-Abcha, Chris Jacob, Jelena Arnautovic, Manel Boumegouas, Steven Do, Krishna Meka, Matthew Wilcox and 1 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Heart, lung & circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. New-Onset, But Not Chronic Atrial Fibrillation, Is a Significant Factor Contributing to Mortality Among Patients with Severe COVID-19.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  4. Article
  5. Review
  6. Cardiovascular Complications in Patients Hospitalized for COVID-19: A Cohort Study in Havana, Cuba.Cardiovascular revascularization medicine : including molecular interventions · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Clinical outcomes of COVID-19 infection in patients with pre-existing cardiovascular disease.American heart journal plus : cardiology research and practice · 2022
    Article
  11. Review
  12. Article
  13. COVID-19 and the CHAClinical medicine & research · 2021
    Article
  14. Article
  15. Arrhythmias in COVID-19.Methodist DeBakey cardiovascular journal · 2021
    Review
  16. Incidence and Clinical Outcomes of New-Onset Atrial Fibrillation in Critically lll Patients with COVID-19: A Multicenter Cohort Study - New-Onset Atrial Fibrillation and COVID-19.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Randy J IpDivision of Cardiovascular Medicine, Ascension Macomb, Warren, MI, USA. Electronic address: randyip.stjohn@gmail.com.
Abbas AliDivision of Cardiology, West Virginia University, Morgantown, WV, USA.
Zulfiqar Qutrio BalochDivision of Cardiovascular Medicine, Michigan State University, Sparrow Hospital, Lansing, MI, USA.
Abdullah Al-AbchaDivision of Cardiovascular Medicine, Michigan State University, Sparrow Hospital, Lansing, MI, USA.
Chris JacobDivision of Hospital Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Jelena ArnautovicDivision of Cardiovascular Medicine, Ascension Macomb, Warren, MI, USA.
Manel BoumegouasDivision of Cardiovascular Medicine, Michigan State University, Sparrow Hospital, Lansing, MI, USA.
Steven DoDivision of Cardiovascular Medicine, Michigan State University, Sparrow Hospital, Lansing, MI, USA.
Krishna MekaDivision of Cardiovascular Medicine, Ascension Macomb, Warren, MI, USA.
Matthew WilcoxDivision of Cardiovascular Medicine, Michigan State University, Sparrow Hospital, Lansing, MI, USA.
John IpDivision of Cardiovascular Medicine, Michigan State University, Sparrow Hospital, Lansing, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCertain patient demographics and biomarkers have been suggested to predict survival in patients infected with COVID-19. However, predictors of outcome in patients who are critically ill are unclear. MATERIALS AND

methodsWe performed a multicentre analysis of 171 consecutive patients with confirmed COVID-19 who were admitted to the intensive care unit (ICU) between 1 March 2020 and 30 April 2020 and were followed until 23 May 2020. Demographic data, past medical history, laboratory values, echocardiographic and telemetry data were analysed. Patient status was classified as either alive or deceased at hospital discharge or the end of follow-up period.

resultsMean patient age was 66±13 and 57% were male. Mortality rate of this ICU cohort at the end of follow-up was 46.2%. A multivariable logistic regression analysis identified the presence or history of atrial fibrillation (Odds Ratio 4.8, p=0.004) as a significant cardiovascular attribute that contributed to increased mortality.

conclusionMortality of critically ill COVID-19 patients is high. This study suggests a relationship between atrial fibrillation and increased mortality from COVID-19. Early aggressive treatment patients with high risk characteristics, such as atrial fibrillation could improve clinical outcome.

Indexed as

AdultAgedAged, 80 and overAtrial FibrillationCOVID-19Critical IllnessFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSARS-CoV-2Survival RateAtrial fibrillationCoronavirusCOVID-19Mortality

Identifiers

PMID33781697
PMCPMC7936539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.